2005—2014年CHINET肠杆菌属细菌耐药性监测

发布时间：2018-03-05 09:12

本文选题：细菌耐药性监测　切入点：肠杆菌属　出处：《中国感染与化疗杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的了解CHINET细菌耐药性监测网2005—2014年肠杆菌属细菌的分布及其耐药性变化趋势。方法 CHINET细菌耐药性监测网2005—2014年临床分离的肠杆菌属细菌20 558株,采用纸片扩散法或自动化仪器法进行抗菌药物敏感性试验,药敏结果按CLSI 2014年标准判读。结果 10年间,肠杆菌属细菌的检出率呈上升趋势:2005年为3.5%,2014年为4.3%。20 558株肠杆菌属细菌中,以阴沟肠杆菌为主,占71.1%(14 617/20 558),其次为产气肠杆菌,占20.1%(4 129/20 558)。菌株主要分离自呼吸道标本,占55.2%(11 358/20 558)。药敏数据显示,肠杆菌属细菌对头孢唑林和头孢西丁的耐药率高(90%),对头孢吡肟、哌拉西林-他唑巴坦、头孢哌酮-舒巴坦、阿米卡星、庆大霉素、环丙沙星、亚胺培南、美罗培南和厄他培南的耐药率低(30%)。不同科室分离株对常用抗菌药物的耐药率存在差异,ICU、内科、外科、门急诊和儿科中,ICU和外科分离株耐药现象严重。多重耐药菌株(MDR)的分离率在下降,但耐碳青霉烯类的肠杆菌属细菌(CRE)分离率在升高。MDR和CRE主要分布在ICU和外科,且耐药现象严重。MDR仅对亚胺培南、美罗培南和厄他培南的耐药率30%,CRE仅对阿米卡星和环丙沙星的耐药率35%。结论 CHINET细菌耐药性监测网中肠杆菌属细菌对测试抗菌药物的耐药率自2011年起呈下降趋势,但CRE菌株日趋增加,应采取有效措施遏制此类菌株在医院的传播扩散。
[Abstract]:Objective to investigate the distribution of Enterobacter bacteria in CHINET bacterial drug resistance monitoring network from 2005 to 2014 and the trend of drug resistance. Methods 20 558 strains of Enterobacter bacteria were isolated from CHINET bacterial Drug Resistance Monitoring Network from 2005 to 2014. The susceptibility test of antimicrobial agents was carried out by disk diffusion method or automatic instrument method. The results of antimicrobial susceptibility were interpreted according to CLSI 2014 standard. The detection rate of Enterobacter bacteria showed an upward trend: in 2005 it was 3.5, and in 2014 it was 4.3.20,558 strains of Enterobacterium were mainly Enterobacter cloacae, accounting for 71. 1% 14 617/20 558G, followed by Enterobacter aerogenes, accounting for 20. 1% 129/20 5580.The strains were mainly isolated from respiratory tract specimens. The drug sensitivity data showed that Enterobacter bacteria had high drug resistance to cefazolin and cefoxitin, and to cefepime, piperacillin-tazobactam, cefoperazone-sulbactam, amikacin, gentamicin, ciprofloxacin, cefoperazone-sulbactam, amikacin, gentamicin, ciprofloxacin, cefpiraxime, cefoperazone-sulbactam, amikacin, gentamicin, ciprofloxacin, The resistance rates of imipenem, meropenem and ertapenem were low. In outpatient and pediatrics, the drug resistance of ICU and surgical isolates was serious. The isolation rate of multidrug resistant strains was decreasing, but the isolation rate of carbapenem resistant Enterobacterium was increasing. MDR and CRE were mainly distributed in ICU and surgery. And the drug resistance is serious. MDR is only for imipenem, The drug resistance rate of meropenem and ertapenem was only 35% for amikacin and ciprofloxacin. Conclusion the resistance rate of Enterobacter spp to test antimicrobial agents in CHINET bacterial resistance monitoring network has been decreasing since 2011. However, CRE strains are increasing day by day, and effective measures should be taken to curb the spread of these strains in hospitals.
【作者单位】：华中科技大学同济医学院附属同济医院检验科;北京协和医院;上海交通大学医学院附属瑞金医院;复旦大学附属华山医院;安徽医科大学第一附属医院;上海交通大学附属儿童医院;浙江大学附属第一医院;甘肃省人民医院;天津医科大学总医院;复旦大学附属儿科医院;广州医科大学附属第一医院;四川大学华西医院;昆明医科大学第一附属医院;新疆医科大学第一附属医院;北京医院;中国医科大学附属第一医院;重庆医科大学附属第一医院;浙江大学医学院附属邵逸夫医院;内蒙古医科大学附属医院;
【分类号】：R446.5

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