2009—2014年重庆地区儿童感染肺炎链球菌的耐药性及血清分型研究

发布时间：2018-03-09 12:33

  本文选题：肺炎链球菌　切入点：耐药性　出处：《中国抗生素杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的了解重庆地区儿童2009—2014年肺炎链球菌对常用抗菌药物的耐药性及血清型分布。方法分析2009—2014年从临床感染患者标本中检出的11671株肺炎链球菌的分布特征,采用BD Phoenix 100测定肺炎链球菌对18种抗菌药物的药敏试验,按美国临床实验室标准化委员会(CLSI)标准判断结果。荚膜肿胀试验进行血清学分型,并计算疫苗(PCV 7、PCV 11、PCV 13)覆盖率。结果 6年共分离肺炎链球菌11671株,检出率为14.37%;2岁组肺炎链球菌分离率为50.7%,2~5岁和5岁组的分离率30.8%和18.5%,81.5%的分离株在≤5岁年龄段;未检出耐万古霉素和替考拉宁的肺炎链球菌。肺炎链球菌对利奈唑胺、左氧氟沙星、氧氟沙星、利福平和泰利霉素的耐药率低,分别为:0.02%、0.21%、0.08%、1.13%和3.15%;对四环素、阿奇霉素、红霉素、克林霉素、复方磺胺甲VA唑的耐药率均70%以上。2009—2014年肺炎链球菌对美罗培南、左氧氟沙星和利奈唑胺的耐药率无明显改变(P0.05),其余受试药物的耐药率均有明显改变(P0.05)。600株肺炎链球菌共鉴定出20个血清型,常见的肺炎链球菌血清型为19F、19A、6B、23F,PCV 13覆盖率为75.5%。结论肺炎链球菌是导致重庆地区儿童呼吸道感染的重要病原菌,对不同抗生素的耐药性不同,并随着时间而变化,应重视细菌耐药性监测,根据药敏试验结果合理选用抗菌药物。重庆地区肺炎链球菌临床分离株以19F、19A、6B、23F血清型为主,推荐PCV 13疫苗预防肺炎链球菌感染。
[Abstract]:Objective to investigate the drug resistance and serotype distribution of Streptococcus pneumoniae from 2009 to 2014 in Chongqing area. Methods the distribution characteristics of 11671 strains of Streptococcus pneumoniae isolated from clinical infected patients in 2009-2014 were analyzed. The susceptibility test of Streptococcus pneumoniae to 18 kinds of antimicrobial agents was determined by BD Phoenix 100, and the results were judged according to the standard of American Clinical Laboratory Standardization Committee. Results 11671 strains of Streptococcus pneumoniae were isolated in 6 years. The detection rate was 14.3710%. The isolation rate of Streptococcus pneumoniae was 50.7% in the group of 5 and 5 years of age, and 81.5% of the isolates were in the age group of 鈮，

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