2005—2014年CHINET肠球菌属细菌耐药性监测

发布时间：2018-03-11 16:55

本文选题：肠球菌属　切入点：细菌耐药性监测　出处：《中国感染与化疗杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的总结2005—2014年中国主要地区临床分离肠球菌属对各类抗菌药物的耐药性变迁。方法 CHINET细菌耐药性监测网各医院按统一方案、采用统一的材料、方法(K-B法)和判断标准进行肠球菌属细菌的耐药性监测。结果2005—2014年共分离到42 185株非重复肠球菌属细菌,最常见菌种为粪肠球菌(47.3%)、屎肠球菌(43.5%)、鸟肠球菌(1.9%)、鹑鸡肠球菌(1.8%)、铅黄肠球菌(0.6%)。10年间,肠球菌属细菌的检出率呈下降波动趋势:2005年为9.1%,2014年为8.7%。肠球菌属对利奈唑胺、万古霉素、替考拉宁、替加环素仍高度敏感,耐药率4%,万古霉素耐药粪肠球菌和屎肠球菌检出率分别为0.3%、3.2%。粪肠球菌对氨苄西林、高浓度庆大霉素耐药率分别为10.9%、38.0%,尿液标本分离株对呋喃妥因、磷霉素耐药率低,分别4.8%、6.2%,粪肠球菌耐药率有逐年下降趋势;屎肠球菌耐药率明显高于粪肠球菌,对氨苄西林、环丙沙星、利福平耐药率80%,对高浓度庆大霉素耐药率为60.8%,对氯霉素耐药率为7.0%,对万古霉素耐药率从2005年0.6%上升至2014年4.2%。结论肠球菌对利奈唑胺、万古霉素、替考拉宁、替加环素依然保持较好的敏感性,但屎肠球菌中万古霉素耐药率有逐年增加趋势,应引起重视。
[Abstract]:Objective to summarize the changes of antimicrobial resistance in clinical isolates of Enterococcus from 2005 to 2014 in major regions of China. Methods the hospitals of the CHINET bacterial Drug Resistance Surveillance Network adopted uniform materials according to the unified program. Methods Drug resistance of Enterococcus bacteria was monitored by K-B method and judging criteria. Results 42,185 strains of non-Enterococcal bacteria were isolated from 2005 to 2014. The most common bacteria species were Enterococcus faecalis 47.3, Enterococcus faecium 43.5, Enterococcus faecium 1.9., Enterococcus quail 1.8p, Enterococcus lead 0.60.In the past 10 years, the detection rate of Enterococcus bacteria showed a downward trend: in 2005 it was 9.1and in 2014 it was 8.7. Teicoplanin and tegicycline were still highly sensitive, and the drug resistance rate was 4%. The detectable rates of vancomycin resistant Enterococcus faecalis and Enterococcus faecium were 0.3 and 3.2 respectively. The drug resistance rates of high concentration gentamicin were 10.9 and 38.0, respectively. The resistance rate of urine samples to furantoin and fosfomycin was low, and the resistance rate of Enterococcus faecalis was decreasing year by year, and the resistance rate of Enterococcus faecium was significantly higher than that of Enterococcus faecalis, and the resistance rate to ampicillin was higher than that of Enterococcus faecium. The resistance rates of ciprofloxacin, rifampicin, gentamicin, chloramphenicol and vancomycin increased from 0.6% on 2005 to 4.2 on 2014. Tegacycline is still sensitive, but vancomycin resistance rate in Enterococcus faecium is increasing year by year, which should be paid more attention to.
【作者单位】：浙江大学附属第一医院传染病诊治国家重点实验室;浙江大学医学院附属邵逸夫医院;上海交通大学医学院附属瑞金医院;北京协和医院;华中科技大学同济医学院附属同济医院;复旦大学附属华山医院;复旦大学附属儿科医院;广州医科大学附属第一医院;北京医院;重庆医科大学附属第一医院;新疆医科大学第一附属医院;上海交通大学附属儿童医院;甘肃省人民医院;安徽医科大学第一附属医院;昆明医科大学第一附属医院;天津医科大学总医院;四川大学华西医院;内蒙古医科大学附属医院;中国医科大学附属第一医院;
【分类号】：R446.5

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