纳米增效剂对连续波与脉冲波HIFU消融兔肝肿瘤的作用比较

发布时间：2018-03-18 14:51

本文选题：脉冲波高强度聚焦超声　切入点：连续波高强度聚焦超声　出处：《中国超声医学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨纳米增效剂对连续波HIFU(CHIFU)与脉冲波HIFU(PHIFU)消融肿瘤的增效作用。方法 41只荷瘤兔随机取1只观察建模情况。其余40只随机分为A、B、C、D 4组,分别为单纯CHIFU组、CHIFU联合增效剂组、单纯PHIFU组、PHIFU联合增效剂组(PHIFU组占空比均为50%),每组10只,超声监控下对兔肝肿瘤进行HIFU辐照。结果能效因子:CHIFU联合增效剂组小于单纯CHIFU组,PHIFU联合增效剂组小于单纯PHIFU组,PHIFU联合增效剂组小于CHIFU联合增效剂组(P0.05)。皮肤损伤:PHIFU联合增效剂组小于其余各组。转归:各组均可有效控制肿瘤转移。结论 PHIFU联合纳米增效剂比CHIFU联合纳米增效剂治疗肿瘤效率、安全性更高,转归时间缩短。
[Abstract]:Objective to investigate the synergistic effect of nano-synergist on tumor ablation by continuous wave HIFUU (CHIFU) and pulsed wave HIFU (PHIFU). Methods A total of 41 rabbits were randomly selected to observe the model. The other 40 rabbits were randomly divided into two groups: CHIFU group (n = 41) and CHIFU group (n = 40). The duty ratio of PHIFU combined with synergist group was 50, 10 rats in each group. Results the energy efficiency factor:% CHIFU combined synergist group was smaller than that of pure CHIFU group and PHIFU combined synergist group was smaller than CHIFU combined synergist group (P 0.05). Conclusion PHIFU combined with nano-synergist is more effective than CHIFU combined with nano-synergist in the treatment of tumor. Higher safety and shorter return time.
【作者单位】：重庆医科大学生物医学工程学院省部共建国家重点实验室培育基地-重庆市超声医学工程重点实验室重庆市生物医学工程学重点实验室;
【基金】：国家973计划项目(No.2011CB707900) 国家自然科学基金(No.81127901,11274404)
【分类号】：R735.7;R454.3

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