Th17和Treg细胞及相关细胞因子在红细胞输注无效患者外周血中的变化

发布时间：2018-03-19 21:25

本文选题：红细胞输注无效　切入点：Th细胞　出处：《中国输血杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的研究Th17细胞和Treg细胞及相关细胞因子在红细胞输注无效患者外周血中的水平变化。方法采用流式细胞术检测36名反复输注红细胞患者(分为无效组和有效组)外周血中Th17及Treg细胞的变化,采用ELISA方法检测血清中IL-6、IL-23、IL-17和TGF-β的浓度。结果输注无效组患者输血后Th17细胞、IL-6、IL-23和IL-17水平较输血前明显升高(P0.05),Treg细胞和TGF-β水平较输血前明显降低(P0.05),差异有统计学意义;有效组患者Th17、Treg、IL-6、IL-23、IL-17和TGF-β水平无改变(P0.05)。结论红细胞输注无效患者的免疫系统处于活跃状态,Th17、Treg、IL-6、IL-23、IL-17和TGF-β水平变化,这些原因可能参与红细胞输注无效免疫发病过程。
[Abstract]:Objective to study the changes of Th17 cells, Treg cells and related cytokines in peripheral blood of patients with ineffective erythrocyte transfusion. Methods flow cytometry was used to detect 36 patients with repeated red blood cell transfusion (divided into ineffective group and effective group). The changes of Th17 and Treg cells in peripheral blood, The serum levels of IL-6, IL-23, IL-17 and TGF- 尾 were detected by ELISA method. Results the levels of IL-6, IL-23 and IL-17 in Th17 cells were significantly higher than those before blood transfusion in patients with ineffective transfusion, and the levels of P0.05Treg cells and TGF- 尾 were significantly lower than those before blood transfusion (P 0.05). In the effective group, the levels of IL-23 IL-17 and TGF- 尾 were not changed. Conclusion the immune system of the patients with ineffective erythrocyte transfusion is active and the levels of IL-23 IL-17 and TGF- 尾 may be involved in the pathogenesis of ineffective red blood cell transfusion.
【作者单位】：大连市血液中心;大连市疾病预防控制中心理化所;
【分类号】：R457.1

【相似文献】