黏菌素联用不同药物对老年患者多药耐药鲍氏不动杆菌体外联合药敏研究

发布时间：2018-03-20 20:53

本文选题：鲍氏不动杆菌　切入点：老年患者　出处：《中华医院感染学杂志》2016年17期 　论文类型：期刊论文

【摘要】：目的对老年患者多耐药和泛耐药鲍氏不动杆菌进行体外联合药敏试验,为临床治疗提供可靠的理论依据。方法采用琼脂稀释法对2012年1月-2013年12月114株多药耐药鲍氏不动杆菌进行体外联合药敏试验,联合方案共3种:头孢哌酮/舒巴坦(SCF)+多黏菌素E(PE)、多黏菌素E+美罗培南(MEM)、米诺环素(MH)+多黏菌素E,计算抑菌浓度(FIC)指数判断联用效果。结果 SCF和PE联合,94.7%表现为协同或相加,以相加为主;PE和MEM联合,99.1%表现为协同或相加,其中约40.0%为协同;PE和MH联合,99.1%表现为协同或相加,以协同作用为主,所有组合均无拮抗作用。结论 PE与SCF、MEM、MH体外联合应用效果显著,联用能有效降低单药最低抑菌浓度(MIC)值。
[Abstract]:Objective to elderly patients with multi drug resistant and pan resistant Acinetobacter baumannii by in vitro drug sensitivity test, and provide a reliable theoretical basis for clinical treatment. Methods using agar dilution method on the January 2012 -2013 year in December of 114 strains of multi drug resistant Acinetobacter baumannii by in vitro drug sensitivity test, combined for a total of 3 kinds: Cefoperazone / Shubatan (SCF) and polymyxin E (PE), polymyxin E+ meropenem (MEM), minocycline (MH) + polymyxin E, calculate the inhibitory concentration (FIC) index to estimate the combined effect. The results of SCF and PE combined, 94.7% showed a synergistic or additive, the additive; PE combined with MEM, 99.1% showed a synergistic or additive, of which about 40% for PE and MH, Co; 99.1% showed a synergistic or additive, with synergistic effect, all combinations are no antagonistic effect. Conclusion PE and SCF, MEM, MH in vitro significantly combined effect, combined with single drug can effectively reduce the Low bacteriostasis concentration (MIC) value.

【作者单位】：解放军总医院南楼检验科;解放军302医院检验科;
【基金】：全军医学科技“十二五”科研项目重点基金资助项目(BWS11-C073)
【分类号】：R446.5

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