2011-2014年哈励逊医院铜绿假单胞菌的临床分布特点及耐药变迁

发布时间：2018-03-21 01:30

本文选题：铜绿假单胞菌　切入点：分布特点　出处：《现代预防医学》2016年03期 　论文类型：期刊论文

【摘要】：目的探讨我院铜绿假单胞菌的临床分布特点及耐药变迁,为抗菌药物临床合理使用提供有效依据。方法采用VITEK-2全自动细菌鉴定及药敏分析仪对2011年1月-2014年12月本院检出的1818铜绿假单胞菌进行鉴定及药敏分析。结果铜绿假单胞菌检出率逐年增加,检出前三位的科室分别是:呼吸内科、重症医学科和神经外科。痰标本检出最多占74.2%。药敏结果显示,氨苄西林/舒巴坦、头孢替坦、头孢呋辛耐药率上升最为显著,分别从2011年的78.2%、68.8%、75.2%升高至2014年的95.7%、92.6%、96.7%。阿米卡星耐药率4年均10%,哌拉西林、头孢吡肟、庆大霉素和哌拉西林/他唑巴坦耐药率呈逐年下降趋势。结论铜绿假单胞菌感染以下呼吸道为主,收治危重症患者的科室分布较多,多重耐药菌检出比例逐年增高,耐药机制复杂,临床应根据药敏结果合理选用抗生素。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa in our hospital. Methods VITEK-2 automatic bacterial identification and drug sensitivity analyzer were used to identify and analyze 1818 Pseudomonas aeruginosa isolated from January 2011 to December 2014. The detection rate of Pseudomonas aeruginosa increased year by year. The first three departments were: Department of Respiratory Medicine, Department of intensive Medicine and Neurosurgery. Sputum samples were detected at most 74.2%. Drug sensitive results showed that ampicillin / sulbactam, cefotitan and cefuroxime showed the most significant increase in drug resistance. The drug resistance rate of amikacin increased from 78.2% on 2011 to 95.6% on 2014 from 78.2% to 92.7% on 2014. The drug resistance rate of amikacin was 10% in 4 years, piperacillin, cefepime, cefpyridoxime, piperacillin and cefepime. The resistance rate of gentamicin and piperacillin / tazobactam decreased year by year. Conclusion Pseudomonas aeruginosa infection is the main infection in the respiratory tract, and there are more departments in critically ill patients, and the detection rate of multidrug resistant bacteria increases year by year. The mechanism of drug resistance is complicated, and antibiotics should be selected reasonably according to the results of drug sensitivity.
【作者单位】：衡水哈励逊国际和平医院核医学科;衡水哈励逊国际和平医院核检验科;
【分类号】：R446.5

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