ICU患者肺部感染真菌分析与耐药性研究

发布时间：2018-03-22 11:11

本文选题：重症监护病房　切入点：肺部　出处：《中华医院感染学杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨重症监护病房(ICU)患者肺部感染真菌的分布及耐药性,分析真菌种类及耐药性。方法选取2011年6月-2015年5月于六安医院ICU就诊的172例肺部真菌感染患者临床资料,病原菌分离鉴定按《全国临床检验操作规程》进行常规操作,药敏试验采用K-B纸片法,于MicroScan Waik-AWay-40全自动微生物分析仪进行药敏试验,结果判定参照美国临床实验室标准化研究所(CLSI)规定的标准。结果 172例患者痰液标本共分离真菌218株,以白色假丝酵母菌和热带假丝酵母菌为主,分别占40.37%和21.10%;218株真菌除对氟康唑和伊曲康唑敏感率90.00%外,对氟胞嘧啶、两性霉素B和伏立康唑的敏感率分别为97.25%、98.62%和92.66%。结论白色假丝酵母菌是ICU肺部真菌感染的主要致病菌,可优先选择氟胞嘧啶、伏立康唑和两性霉素B进行治疗。
[Abstract]:Objective to investigate the distribution and drug resistance of pulmonary infection fungi in intensive care unit (ICU) patients, and to analyze the types and drug resistance of fungi. Methods the clinical data of 172 patients with pulmonary fungal infection from June 2011 to May 2015 in Luan Hospital were selected. The isolation and identification of pathogenic bacteria was performed in accordance with the National procedure for Clinical examination. The drug sensitivity test was carried out by using K-B disk method and MicroScan Waik-AWay-40 automatic microbiological analyzer. Results 218 strains of fungi were isolated from sputum of 172 patients, mainly Candida albicans and Candida tropicalis. In addition to fluconazole and itraconazole, the susceptibility rates to fluconazole, amphotericin B and voriconazole were 97.2598.62% and 92.66%, respectively. Conclusion Candida albicans is the main pathogen of ICU pulmonary fungal infection. Fluorocytosine, volconazole and amphotericin B are preferred for treatment.
【作者单位】：安徽医科大学;安徽医科大学附属六安医院急诊医学科;安徽医科大学附属省立医院重症医学科;
【基金】：安徽省自然科学基金资助项目(1208085)
【分类号】：R446.5

【相似文献】