多药耐药鲍氏不动杆菌医院感染最新研究进展

发布时间：2018-03-23 20:31

本文选题：鲍氏不动杆菌　切入点：多药耐药　出处：《中华医院感染学杂志》2016年10期

【摘要】：不动杆菌属中致病性最强的鲍氏不动杆菌,由于其具有极强的环境适应能力和快速获得并传播耐药性的能力,因而极易造成医院内的播散流行;鲍氏不动杆菌引起的医院感染包括呼吸机相关性肺炎、尿路感染、败血症、创口感染及中枢神经系统感染等,严重者可危及生命;近年来,多药耐药鲍氏不动杆菌(MDRAB)的分离率逐渐增加,给临床抗感染治疗和医院感染的控制带来极大挑战,尽管临床上不断推出高效、广谱的抗菌药物,使用先进的消毒洁净技术等防治感染,但MDRAB引起的医院感染问题仍日益突出;该研究综述了MDRAB引起的医院感染的现状、常见耐药机制、危险因素、治疗和预防策略,以期为临床和医院感染控制提供参考。
[Abstract]:Acinetobacter baumannii which has the strongest pathogenicity in the genus Acinetobacter baumannii has strong ability of adapting to the environment and the ability to quickly acquire and spread drug resistance so it is easy to cause the spread and epidemic in hospital. Nosocomial infections caused by Acinetobacter baumannii include ventilator-associated pneumonia, urinary tract infection, sepsis, wound infection and central nervous system infection. The increasing isolation rate of multidrug resistant Acinetobacter baumannii (MDRAB) has brought great challenges to clinical anti-infection treatment and control of nosocomial infection, despite the continuous introduction of highly efficient, broad-spectrum antimicrobial agents in clinical practice. The problem of nosocomial infection caused by MDRAB is still more and more prominent using advanced disinfection and cleaning technology. This study summarizes the current situation of nosocomial infection caused by MDRAB, common drug resistance mechanism, risk factors, treatment and prevention strategy. In order to provide reference for clinical and nosocomial infection control.
【作者单位】：中国医学科学院北京协和医院检验科;中国医学科学院北京协和医学院研究生院;中国医学科学院北京协和医学院;中国医学科学院北京协和医院基本外科;
【基金】：北京协和医学院教育教学改革立项基金资助项目(2014X300901) 卫计委卫生公益性行业科研专项基金资助项目(201402001)
【分类号】：R446.5

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