颅内碳青酶烯类耐药与敏感肠杆菌科细菌感染的治疗及其经济学损失分析

发布时间：2018-03-31 09:44

本文选题：颅内感染　切入点：抗菌药物治疗　出处：《中华医院感染学杂志》2016年18期

【摘要】：目的探讨碳青酶烯类耐药肠杆菌(CRE)和碳青酶烯类敏感肠杆菌(CSE)颅内感染治疗效果和直接经济损失的差异,分析颅内感染治疗效果的影响因素。方法采用回顾性调查方法,选取医院2014年1月-2015年12月CRE和CSE颅内感染患者,按1∶1比例配对,将患者分为CRE组和CSE组,各12例;比较CRE和CSE颅内感染治疗效果和住院费用的差异,分析耐药情况和抗菌药物联合使用对治疗效果的影响。结果发现CRE颅内感染治愈率为41.67%,CSE颅内感染治愈率为91.67%,两组差异有统计学意义(P0.05);CRE组每床日医疗费用为7 008.82元,CSE组每床日医疗费用为2 777.75元,两组差异有统计学意义(Z=-2.252,P=0.024);碳青酶烯类联合其他药物治疗CRE颅内感染是常见的组合,治愈率66.67%,CSE颅内感染治疗以碳青酶烯类单药治疗为主,治愈率为91.67%;鞘内局部注射抗菌药物局部治疗,未提高CRE颅内感染的治愈率。结论 CRE颅内感染可明显增加患者的经济损失,临床治疗效果较CSE低,临床应积极采取有效措施进行预防控制。
[Abstract]:Objective to explore the difference between the therapeutic efficacy and direct economic loss of enterobacter carbene resistance (CRE) and enterobacterium carboxylerenes (CSE) in the treatment of intracranial infection, and to analyze the factors affecting the therapeutic effect of intracranial infection. Methods retrospective investigation was used. From January 2014 to December 2015, the patients with intracranial infection of CRE and CSE were divided into two groups: CRE group and CSE group, according to 1:1 ratio, 12 patients in each group were divided into CRE group and CSE group, and the difference of treatment effect and hospitalization cost between CRE group and CSE group was compared. The effect of drug resistance and combined use of antimicrobial agents on the therapeutic effect was analyzed. The results showed that the cure rate of intracranial infection of CRE was 41.67 yuan, and the cure rate of intracranial infection of CRE was 91.67 yuan. The difference between the two groups was statistically significant (P 0.05). The daily medical cost per bed was 7 008.82 yuan in the CRE group. The daily medical cost per bed in CSE group was 2 777.75 yuan. There was significant difference between the two groups in the treatment of CRE intracranial infection, the cure rate was 66.67%, the cure rate was 66.67%, and the cure rate was 66.67%, the cure rate was 66.67%, the cure rate was 66.67%, and the cure rate was 66.67%, and the cure rate was 66.67%, and the cure rate was 66.67%. The cure rate was 91.67.The local treatment of intrathecal injection of antimicrobial agents did not improve the cure rate of CRE intracranial infection. Conclusion Intracranial CRE infection can significantly increase the economic loss of patients, and the clinical effect is lower than that of CSE. Effective measures should be taken in clinical prevention and control.
【作者单位】：福建省肿瘤医院医院感染管理科;中南大学湘雅医院感染控制中心;
【基金】：湖南省自然科学基金(13JJ6013) 中南大学湘雅医院院内临床基金(2014-11);中南大学校级大数据基金(2014-33)
【分类号】：R446.5

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