2010-2014年肠球菌属临床分布与耐药性监控

发布时间：2018-03-31 11:24

本文选题：粪肠球菌　切入点：屎肠球菌　出处：《中华医院感染学杂志》2016年19期

【摘要】：目的分析肠球菌属感染的临床分布及其耐药性,为临床合理使用抗菌药物提供依据。方法收集2010-2014年医院临床分离肠球菌属,应用VITEK-2Compact微生物全自动分析系统进行鉴定,采用AST-GP67药敏卡进行药敏试验,用WHONET5.6软件分析肠球菌属的分布及耐药性。结果 2010-2014年共分离出482株肠球菌属,其中粪肠球菌286株、屎肠球菌153株,主要来源于尿液、引流液和血液;粪肠球菌对氨苄西林、青霉素、红霉素、环丙沙星、左氧氟沙星、莫西沙星、高浓度庆大霉素、高浓度链霉素、呋喃妥因、万古霉素等10种抗菌药物耐药率分别为24.1%、19.2%、66.4%、18.5%、19.2%、19.2%、38.1%、30.4%、0.3%、0.3%,明显低于屎肠球菌94.1%、92.2%、91.5%、93.5%、88.2%、89.5%、70.6%、49.0%、40.5%、2.6%,粪肠球菌对喹奴普汀/达福普汀、四环素耐药率分别为100.0%、76.6%,明显高于屎肠球菌0、42.5%;2010-2014年粪肠球菌及屎肠球菌对常用抗菌药物耐药率无明显趋势变化。结论粪肠球菌和屎肠球菌主要分布于尿液、引流液和血液,对多种抗菌药物的耐药率存在较大差异,临床应根据药敏试验结果合理选择抗菌药物。
[Abstract]:Objective to analyze the clinical distribution and drug resistance of Enterococcus infection in order to provide evidence for rational use of antimicrobial agents. Methods Clinical isolates of Enterococcus from 2010 to 2014 were collected and identified by VITEK-2Compact microorganism automatic analysis system. The distribution and drug resistance of Enterococcus were analyzed by WHONET5.6 software. Results A total of 482 strains of Enterococcus were isolated from 2010 to 2014, including 286 strains of Enterococcus faecalis and 153 strains of Enterococcus faecium, mainly from urine. Drainage fluid and blood; Enterococcus faecalis against ampicillin, penicillin, erythromycin, ciprofloxacin, levofloxacin, moxifloxacin, high concentration gentamicin, high concentration streptomycin, furantoin, The resistance rates of 10 antimicrobial agents, including vancomycin and so on, were 24.1and 19.2i, respectively, and the resistance rates were 66.45 and 19.219.2, respectively, and there were 38.1and 30.40.34 in the area, which were significantly lower than those of Enterococcus faecium 94.112.92. 2 and 993.588.28.28.50.75 and 49.00.45, respectively. Enterococcus faecalis had antiquinoputine / Dafoputin, and had a greater resistance to quinaputin / Dafopudine, which was significantly lower than that of Enterococcus faecium 94.51, 88.28.22, 89.50.6 and 49.00.45, and it was lower than that of Enterococcus faecium. The resistance rate of tetracycline to antibiotics was 100.0 and 76.6, respectively, which was significantly higher than that of Enterococcus faecium 02.5. There was no significant change in resistance rate of Enterococcus faecalis and Enterococcus faecium to common antimicrobial agents from 2010 to 2014. Conclusion Enterococcus faecalis and Enterococcus faecium are mainly distributed in urine, drainage fluid and blood. There is great difference in drug resistance rate of many kinds of antimicrobial agents, so it is necessary to select antimicrobial agents according to the results of drug sensitivity test in clinic.
【作者单位】：浙江萧山医院检验科;
【基金】：浙江省医药卫生科技计划基金资助项目(2012KYB171)
【分类号】：R446.5

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