艰难梭菌感染患者的临床特征分析

发布时间：2018-04-01 12:32

本文选题：菌株　切入点：艰难梭菌　出处：《广东医学》2016年S1期

【摘要】：目的研究艰难梭菌感染患者的临床特征,为临床对此类感染患者的诊断及治疗提供依据。方法回顾性分析感染性腹泻患者的艰难梭菌分离情况以及临床感染特点。结果从291份感染性腹泻标本中分离出33株艰难梭菌,阳性率为10.3%(18/174),其中26株为产A/B毒素菌株(12例患者)。艰难梭菌主要分离自老年男性,均具有严重基础疾病,且使用过质子泵抑制剂和多种广谱抗菌药物;粪便常规和血液学相关指标对艰难梭菌感染及产毒与否具有一定的指示作用。结论严重的艰难梭菌感染患者病死率高,且易引起院内感染的播散,医院可以根据此类患者的临床特征进行规范干预,从而有效地控制院内感染的爆发。
[Abstract]:Objective to study the clinical characteristics of patients infected with Clostridium difficulty. Methods A retrospective analysis was made on the isolation and clinical infection characteristics of Clostridium difficulty in patients with infectious diarrhea. Results 33 strains of Clostridium difficulty were isolated from 291 specimens of infectious diarrhea. The positive rate was 10.3 / 174%, of which 26 strains were A- / B toxin producing strains (12 cases). Clostridium diffusa was isolated mainly from old men, all of them had serious basic diseases and had been treated with proton pump inhibitors and a variety of broad-spectrum antimicrobial agents. The stool routine and hematological indexes can indicate the infection of Clostridium difficulty and whether it can produce poison or not. Conclusion the mortality rate of patients with severe Clostridium difficulty infection is high, and it is easy to cause the spread of nosocomial infection. Hospital intervention can be standardized according to the clinical characteristics of such patients to effectively control the outbreak of nosocomial infection.
【作者单位】：广东省人民医院(广东省医学科学院)临床微生物室;
【基金】：广东省科技计划项目(编号:2012B031800162)
【分类号】：R446.5

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