高强度聚焦超声螺旋扫描形成的组织损伤研究

发布时间：2018-04-05 06:27

本文选题：高强度聚焦超声　切入点：组织损伤　出处：《声学学报》2016年05期

【摘要】：为满足高强度聚焦超声(HIFU)治疗对组织损伤均匀性和高效性的需求,理论及实验研究了连续扫描模式下HIFU沿螺旋扫描路径形成的组织损伤。基于Khokhlov-Zabolotskaya-Kuznetsov方程和生物传热方程建立了声热耦合模型,数值模拟了螺旋路径栅格距离为3 mm和4 mm时不同扫描速度下HIFU辐照体模的温度场和组织损伤分布,并采用凝胶体模进行了实验验证。结果表明,采用连续螺旋模式可以使热扩散均匀化,产生分布均匀的热损伤;选择适当的栅格距离和扫描速度,发挥螺旋路径内外圈热扩散的相互影响,可以产生大范围的整体性的热损伤,同时提高治疗效率。本文工作对优化HIFU治疗效果具有指导意义。
[Abstract]:In order to meet the needs of high intensity focused ultrasound (HIFU) treatment of uniformity and efficiency requirements of tissue injury, theoretical and Experimental Research on the tissue damage in a continuous scanning mode HIFU along the spiral scanning path. The formation of the Khokhlov-Zabolotskaya-Kuznetsov equation and the bio heat transfer Fang Chengjian established sound heat coupling model based on the numerical simulation of the spiral path of grid distance is 3 mm and 4 mm HIFU radiation phantom with different scanning speeds of the temperature field and the distribution of tissue damage, and the gel model were carried out. The experimental results show that the continuous spiral patterns can make the thermal diffusion homogenization, heat damage distribution; select the appropriate grid distance and scanning speed, the mutual influence of spiral play the path of inner and outer ring of heat diffusion, thermal damage integrity can produce a large range, and improve the efficiency of treatment. This work is to optimize the HIFU treatment effect Guiding significance.

【作者单位】：近代声学教育部重点实验室南京大学声学研究所;复旦大学信息科学与工程学院;
【基金】：国家自然科学基金资助项目(81127901,81227004,11374155) 国家科技部863项目(2012AA022702)
【分类号】：R445.1;TB559

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