灯盏细辛对脓毒症患者的心肌保护作用

发布时间：2018-04-11 21:37

本文选题：灯盏细辛 + 脓毒症　；参考：《广东医学》2016年23期

【摘要】：目的探讨灯盏细辛对脓毒症患者的心肌保护作用的临床疗效。方法选取70例符合入选诊断标准的脓毒症患者,随机分成对照组(34例)和观察组(36例)。对照组给予磷酸肌酸钠1.0 g/次、2次/d,静脉滴注;硫普罗宁0.2 g/次、1次/d,静脉滴注保护重要脏器功能;另给予原发疾病治疗及抗生素抗炎,补液等常规基础治疗。观察组在常规基础治疗外给予灯盏细辛40 m L/次、1次/d,静脉滴注,疗程为7 d。分别测定各组入院第1、7天的肌红蛋白(MYO)、磷酸肌酸激酶同工酶(CK-MB)、肌钙蛋白(c Tn I)、B型钠尿肽前体(pro-BNP),并应用心脏彩超检查测定左心室射血分数(LVEF)及E/A比值。结果两组患者在治疗后MYO、CK-MB、c Tn I均较治疗前下降,但观察组患者的下降相对比较明显,与对照组比较,差异有统计学意义(P0.05)。同时两组治疗后pro-BNP比较,差异有统计学意义(P0.05);两组治疗后LVEF比较,差异无统计学意义(P0.05);反映心脏舒张功能的E/A比值,观察组与对照组比较,差异有统计学意义(P0.05)。结论灯盏细辛对脓毒症患者的心肌损伤坏死具有一定的保护作用,对改善脓毒症患者的心脏舒张功能具有积极作用。
[Abstract]:Objective to investigate the clinical effect of Erigeron breviscapus on myocardial protection in septic patients.Methods 70 patients with sepsis were randomly divided into control group (n = 34) and observation group (n = 36).In the observation group, 40 mL of Erigeron breviscapus was injected intravenously for 7 days.Results after treatment, MYOG CK-MBN c Tn I decreased significantly in the two groups, but the decrease in the observation group was more obvious than that in the control group, and the difference was statistically significant compared with that in the control group (P 0.05).Conclusion Erigeron breviscapus has a protective effect on myocardial injury and necrosis in septic patients, and has a positive effect on improving cardiac diastolic function in septic patients.
【作者单位】：河北省秦皇岛市第一医院急诊科;海军91126部队医院;
【分类号】：R459.7

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