NICU患者肺炎克雷伯菌感染的环境传播与定植状态研究

发布时间：2018-04-15 17:00

本文选题：神经危重症监护病房 + 肺炎克雷伯菌　；参考：《中华医院感染学杂志》2016年21期

【摘要】：目的分析肺炎克雷伯菌(KP)在神经危重症监护病房(NICU)环境中的传播情况和定植状态,从而为临床KP感染的预防控制提供理论依据。方法对医院NICU2015年1月-10月空气环境和KP感染患者的周围空气和病床单位进行细菌学目标监测,并应用脉冲场凝胶电泳法对于分离出的KP菌株进行同源性分析。结果在收治221例患者中有154例感染患者,感染率为69.68%,其中148例进行病原学检查,检出非重复病原菌99株,其中KP 25株,占25.25%,在NICU感染患者的病房环境细菌学监测中共检出KP 3株,有2株分别来源于1例病毒性脑炎患者的空气和床头柜表面采集标本,1株来源于KP感染患者周围空气标本,对其中27株KP分离株成功分型。在27株菌PFGE谱型中,1521Y和1521、1501和1513、1520和1525为同一型;A'和T'为同一型,且与1503菌株相似度为86.7%。结论 NICU病房环境不但是KP感染的重要传播途径,而且KP能够在NICU的病房空气和床头柜等病床单位环境中定植生存,从而成为重要的感染源。
[Abstract]:Objective to analyze the transmission and colonization status of Klebsiella pneumoniae KPin NICU (Neurocritical Care Unit), so as to provide a theoretical basis for the prevention and control of clinical KP infection.Methods the air environment of NICU2015 from January to October in hospital and the peripheral air and hospital bed units of patients with KP infection were monitored by bacteriological target. The isolated KP strains were analyzed by pulsed field gel electrophoresis (PFGE).Results among 221 cases, 154 cases were infected, and the infection rate was 69.68. Among them, 148 cases were examined by etiology, 99 strains of non-repeated pathogens were detected, 25 strains of KP25 were detected.Three strains of KP were detected by environmental bacteriological monitoring in the wards of patients with NICU infection. Two strains were collected from the air of one case of viral encephalitis and the other from the air around the surface of the bedside table.Among them, 27 KP isolates were successfully typed.Among the 27 strains of PFGE, 1521Y and 1521C1501 and 1513C1520 and 1525 belong to the same type, and the similarity with 1503 strain is 86.7%.Conclusion the environment of NICU ward is not only an important way of transmission of KP infection, but also KP can survive in the air of NICU ward and bedside table, so that KP can become an important source of infection.
【作者单位】：华北理工大学附属开滦总医院神经内科;华北理工大学冀唐学院;华北理工大学附属开滦总医院检验科;河北省神经生物机能重点实验室;
【基金】：河北省医学科学研究重点课题(20150039) 河北省重点研发计划自筹项目(152777211)
【分类号】：R446.5

【相似文献】