颅内感染患者病原菌分布与耐药性监测

发布时间：2018-04-18 14:37

本文选题：颅内感染 + 脑脊液　；参考：《中华医院感染学杂志》2016年03期

【摘要】：目的调查颅内感染患者的病原菌分布特征及其耐药性,为临床颅内感染的治疗与合理用药提供参考。方法采集2013年6月-2015年6月医院120例颅内感染患者脑脊液标本,采用VITEK-2全自动微生物分析仪及配套鉴定卡进行病原菌分离、鉴定,并采用K-B法进行药敏试验,数据采用SPSS14.0软件进行统计分析。结果 120例颅内感染患者脑脊液中检出120株病原菌,革兰阴性菌占44.99%、革兰阳性菌占38.34%、真菌占16.67%;其中假单胞菌属、新型隐球酵母菌、鲍氏不动菌、表皮葡萄球菌为主要病原菌,分别占15.84%、14.17%、13.33%、12.50%;鲍氏不动杆菌及阴沟肠杆菌对头孢唑林、头孢呋辛、头孢噻肟、头孢曲松的耐药率均为100.00%;表皮葡萄球菌、溶血葡萄球菌、金黄色葡萄球菌和肺炎链球菌除对万古霉素和利奈唑胺的耐药率均10.00%外,对其他常用抗菌药物的耐药率均30.00%;真菌除对氟胞嘧啶和伊曲康唑具有一定耐药性外,对其他药物均无耐药性。结论颅内感染病原菌以革兰阴性菌和革兰阳性菌为主,且各类菌的耐药性较严重,应根据药敏试验结果选择合适的抗菌药物。
[Abstract]:Objective to investigate the distribution and drug resistance of pathogenic bacteria in patients with intracranial infection.Methods from June 2013 to June 2015, cerebrospinal fluid (CSF) samples from 120 patients with intracranial infection were collected. The pathogens were isolated and identified by VITEK-2 automatic microbiological analyzer and matching identification card, and the susceptibility test was performed by K-B method.The data were analyzed by SPSS14.0 software.Results 120 strains of pathogenic bacteria were detected in cerebrospinal fluid of 120 patients with intracranial infection. Gram-negative bacteria accounted for 44.99%, Gram-positive bacteria for 38.34 and fungi for 16.67.The pseudomonas, new Cryptococcus yeast, baumerilus, Staphylococcus epidermidis were the main pathogens.The resistance rates of Acinetobacter baumannii and Enterobacter cloacae to cefazolin, cefuroxime, cefotaxime, cefotaxime and cefotriaxone were all 100.00.Staphylococcus epidermidis, Staphylococcus haemolyticus,The resistance rates of Staphylococcus aureus and Streptococcus pneumoniae to vancomycin and linazolamine were 10.00% and 30.00g, respectively, and fungi were resistant to fluocytosine and itraconazole.There was no resistance to other drugs.Conclusion Gram-negative bacteria and Gram-positive bacteria are the main pathogens of intracranial infection, and the drug resistance of all kinds of bacteria is serious. The appropriate antimicrobial agents should be selected according to the results of drug sensitivity test.
【作者单位】：安阳市人民医院神经外科;
【基金】：河南省卫生厅基金资助项目(201303125)
【分类号】：R446.5

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