泛耐药鲍氏不动杆菌医院感染暴发的溯源调查

发布时间：2018-04-20 07:02

本文选题：泛耐药鲍氏不动杆菌 + 医院感染暴发　；参考：《中华医院感染学杂志》2016年20期

【摘要】：目的调查神经外科重症监护病房(NSICU)泛耐药鲍氏不动杆菌医院感染,查找感染源和传播途径,为预防和控制医院感染提供参考依据。方法采集2015年1月初NSICU 4例感染患者标本(气道深部痰)及医务人员手和NSICU物体表面等环境标本,进行培养鉴定和药敏试验,采用16S-23SrRNA基因测序分析技术对分离出的泛耐药鲍氏不动杆菌进行同源性分析。结果 NSICU泛耐药鲍氏不动杆菌感染罹患率达36.36%(4/11),4株菌经16S-23SrRNA基因测序分析,同源性大于98%;NSICU环境监测在呼吸机面屏检出1株泛耐药鲍氏不动杆菌,其耐药谱与4位患者感染的病原菌相似,经16S-23SrRNA基因测序分析,同源性大于98%。结论该院NSICU发生的泛耐药鲍氏不动杆菌医院感染,经同源性分析确认为医院感染暴发,调查显示,患者A为感染源,病原菌可能通过污染的呼吸机面屏间接接触传播,导致本次感染暴发,经积极采取有效控制措施疫情得到及时控制。
[Abstract]:Objective to investigate the nosocomial infection of Acinetobacter baumannii pan-resistant in neurosurgical intensive care unit (ICU), to find out the source of infection and to provide reference for the prevention and control of nosocomial infection. Methods four specimens of NSICU infected patients (deep phlegm in airway), hand and surface of NSICU objects were collected in early January, 2015, and the culture and drug sensitivity tests were carried out. The homology of pan-resistant Acinetobacter baumannii was analyzed by 16S-23SrRNA gene sequencing. Results the infection rate of Acinetobacter baumannii Pan-resistant NSICU was 36.36% and 4 / 11 strains were analyzed by 16S-23SrRNA gene sequencing. A pan-resistant Acinetobacter baumannii was detected on ventilator screen by environmental monitoring of NSICU with more homology than 98%. The drug resistance spectrum was similar to that of the pathogens infected in 4 patients, and the homology was greater than 98 by 16S-23SrRNA gene sequencing. Conclusion the nosocomial infection of Acinetobacter baumannii occurred in NSICU of our hospital was confirmed as nosocomial infection by homology analysis. The investigation showed that patient A was the source of infection and the pathogen might be transmitted indirectly by contaminated ventilator screen. As a result of this infection outbreak, effective control measures were taken to control the epidemic in time.
【作者单位】：南方医科大学珠江医院感染科;
【基金】：广东省省级科技计划项目(2013B021800155)
【分类号】：R446.5;R197.323

【相似文献】