慢性肾衰竭维持性血液透析患者血清甲状旁腺激素水平与机体营养状况的相关性

发布时间：2018-04-29 17:15

本文选题：慢性肾衰竭 + 维持性血液透析　；参考：《中国老年学杂志》2016年19期

【摘要】：目的探讨慢性肾衰竭(CRF)维持性血液透析患者血清甲状旁腺激素(PTH)水平与机体营养状况的相关性。方法 78例CRF维持性血液透析患者为观察组,同期80例健康体检者为对照组;采用微型营养评定法(MNA)评价两组患者营养状况,采用放射免疫法检测血清PTH水平,并对两组相关血清生化指标进行测定。利用Pearson相关分析方法评价血清PTH与相关血清生化指标的相关性。结果观察组患者并发营养不良的发生率为39.74%,明显高于对照组的17.50%(P0.05);血清各指标水平在不同营养状况组间有统计学差异(P0.05),其中PTH、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、C-反应蛋白(CRP)、尿素氮(BUN)、血肌酐(SCr)表现为营养不良潜在营养不良营养正常,血清总蛋白(TP)、白蛋白(ALB)、总胆固醇(TC)、甘油三酯(TG)、血红蛋白(Hb)表现为营养不良潜在营养不良营养正常;相关性分析发现,PTH与MNA、TP、TC、TG、CRP、Hb负相关(P0.05),与BUN、SCr正相关(P0.05),与ALB、HDL-C、LDL-C无相关性(P0.05)。结论 CRF患者并发营养不良发生率较高,血清PTH水平高表达,与机体营养状况有一定的相关性,临床应予以重视,以协助治疗。
[Abstract]:Objective to investigate the correlation between serum PTH and nutritional status in patients with chronic renal failure (CRF) maintenance hemodialysis. Methods 78 patients with CRF maintenance hemodialysis were used as observation group and 80 healthy persons as control group. The nutritional status of the two groups was evaluated by mini-nutrition evaluation method and serum PTH level was measured by radioimmunoassay. The serum biochemical indexes of two groups were measured. The correlation between serum PTH and serum biochemical indexes was evaluated by Pearson correlation analysis. Results the incidence of malnutrition in the observation group was 39.74, which was significantly higher than that in the control group (P 0.05), and the serum levels were significantly different among the groups with different nutritional status (P 0.05), among which PTH, HDL-C and low density lipoprotein were significantly different. Cholesterol LDL-Con C-reactive protein (CRPN), urea nitrogen bun (BUNA), serum creatinine (SCR) showed that the underlying malnutrition was normal. Serum total protein (TPN), albumin (ALB), total cholesterol (TC), triglyceride (TGN), hemoglobin (HB) were found to be normal in malnutrition potential malnutrition, correlation analysis showed that PTH was negatively correlated with MNA-TPTCG-CRPHb (P0.05), positively correlated with BUNSCr (P0.05), and had no correlation with ALBN HDL-CnLDL-C (P0.05). Conclusion the incidence of malnutrition in patients with CRF is high and the expression of serum PTH is high, which is related to the nutritional status of the body. It should be paid more attention to in clinic to assist the treatment.
【作者单位】：曲靖市第一人民医院肾内科;曲靖市第一人民医院呼吸内科;
【分类号】：R692.5

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