外科感染常见病原菌分布及耐药性分析

发布时间：2018-05-05 10:16

本文选题：外科 + 医院感染　；参考：《中国病原生物学杂志》2016年08期

【摘要】：目的了解医院外科感染常见病原菌的分布及其耐药性,为外科院内感染合理选用抗生素提供参考。方法收集医院外科2013年8月~2015年8月住院且发生感染的患者210例,分离培养并鉴定细菌,采用K-B纸片法进行药敏试验,对病原菌的来源、分布及耐药情况进行统计分析。结果210例患者中发生医院感染32例,感染率为15.23%;共检出病原菌65株,以革兰阴性菌为主,占58.46%(38/65),其中大肠埃希菌占27.69%,铜绿假单胞菌占9.23%,肺炎克雷伯菌占6.15%;检出革兰阳性菌23株,占35.38%,,其中金黄色葡萄球菌占16.92%,表皮葡萄球菌、肠球菌及溶血性链球菌分别占7.69%、6.15%和3.08%;大肠埃希菌、铜绿假单胞菌和肺炎克雷伯菌属产ESBLs株分别为10、3和2株,各占相应菌株的55.56%、50.00%和50.00%,未检出对亚胺培南耐药的产ESBLs株;检出MRSA7株,占金黄色葡萄球菌的45.45%,该菌对万古霉素和呋喃妥因的敏感率均为100.00%。检出真菌4株,占6.15%,以白色念珠菌为主。结论医院外科感染以革兰阴性菌为主,该类菌对亚胺培南敏感。医院外科感染及多重耐药情况严重,应作病原菌的分离及药敏试验,合理选用抗菌药物进行抗感染治疗。
[Abstract]:Objective to investigate the distribution and drug resistance of common pathogens in nosocomial infection and to provide reference for the rational selection of antibiotics for nosocomial infection. Methods 210 inpatients with infection from August 2013 to August 2015 were collected and the bacteria were isolated and identified. The drug sensitivity test was carried out by K-B disk method. The origin, distribution and drug resistance of pathogenic bacteria were analyzed statistically. Results among 210 patients, 32 cases had nosocomial infection, the infection rate was 15.23.The pathogenic bacteria were 65 strains, mainly Gram-negative bacteria, accounting for 58.46% of 38% 65% of them, among which Escherichia coli accounted for 27.699.00%, Pseudomonas aeruginosa 9.23%, Klebsiella pneumoniae 6.15B. 23 strains of gram-positive bacteria were detected. Among them, Staphylococcus aureus accounted for 16.92%, Staphylococcus epidermidis, Enterococcus and Streptococcus haemolyticus accounted for 7.69% and 3.08%, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae produced 10% and 2 strains of ESBLs, respectively. 55.56% of the corresponding strains and 50.00% of the corresponding strains, no imipenem resistant ESBLs strains were detected, and the MRSA7 strains, which accounted for 45.45% of Staphylococcus aureus, were sensitive to vancomycin and furantoin, respectively. Four strains of fungi (6.15%) were detected, mainly Candida albicans. Conclusion Gram-negative bacteria are the main infection in hospital surgery, which is sensitive to imipenem. The situation of nosocomial surgical infection and multidrug resistance is serious.
【作者单位】：山东省医学科学院山东省寄生虫病防治研究所;
【分类号】：R446.5;R61

【参考文献】