ABO血型不合的异基因造血干细胞移植骨髓空虚期血型的血清学特性研究

发布时间：2018-05-08 04:10

本文选题：造血干细胞移植 + 血型血清学　；参考：《中国实验血液学杂志》2016年01期

【摘要】：目的:探讨ABO血型不合的异基因造血干细胞移植血型血清学转化规律,为患者输注血液成分的选择提供依据。方法:在干细胞移植前对受者和供者用盐水介质试管法和微柱凝胶法进行ABO及RhD血型鉴定移植后定期检测患者ABO血型抗原强度及抗体滴度的变化。结果:33例ABO血型不合的异基因造血干细胞移植血型转变后ABO血型主要不合组正反定型结果相符率为100%,血型次要不合组正反定型相符率为33.3%,不符率为66.7%,ABO主次要血型不合组正反定型相符率为20%,不符率为80%。结论:ABO血型不合的干细胞移植后,患者血型抗原转变为供者血型,但次侧不合和双向不合血清学血型转换后与正常人比较有明显的统计学差异。
[Abstract]:Objective: to investigate the blood group serological transformation of allogeneic hematopoietic stem cell transplantation (HSCT) with ABO incompatibility, and to provide evidence for the selection of blood components in patients with allogeneic hematopoietic stem cell transplantation. Methods: ABO and RhD blood group identification were carried out before and after transplantation of stem cell recipients and donors by saline medium tube method and microcolumn gel method. The changes of ABO blood group antigen strength and antibody titer were detected periodically after transplantation. Results in 33 cases of ABO blood group incompatibility, the positive and negative typing rate of ABO blood group was 100, that of minor blood group was 33. 3%, and that of primary and secondary blood group was 66. 7%, respectively, after the transformation of allogeneic hematopoietic stem cell transplantation blood group, the rate of positive and negative typing of ABO blood group was 100, 33. 3% and 66. 7% respectively. The conformity rate of positive and negative stereotyping was 20%, and the inconsistency rate was 80%. Conclusion the blood group antigen of the patients changed into donor blood group after the stem cell transplantation with blood group mismatch of: ABO, but there was significant statistical difference between the secondary incompatibility and the bidirectional incompatibility after serological blood group conversion compared with the normal group.
【作者单位】：温州医科大学附属第一医院输血科;
【基金】：温州市科技计划项目(Y20120143)
【分类号】：R446.6

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