台湾儿童血清全氟化合物与血脂关联的性别差异研究

发布时间：2018-05-12 21:19

  本文选题：全氟辛烷磺酸 + 全氟辛酸　； 参考：《生态毒理学报》2016年01期

【摘要】：目的:全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)是广泛应用于工业和生活领域的全氟化合物,在人体及环境介质中均可检出。近几年的流行病学研究表明儿童PFOS和PFOA的暴露水平与血脂水平具有相关性。本研究拟进一步研究血清全氟化合物水平与儿童血脂间关联的性别差异。方法:以台湾儿童为研究对象,分析血清中总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三脂(TG)等生化指标与PFOS和PFOA血清水平的相关性。结果:线性回归模型分析表明男生血清PFOS、PFOA水平与血脂水平具有显著相关性。当男生血清中ln-PFOS和ln-PFOA水平每增加1 ng·m L~(-1)时,TC含量分别增高0.51 mg·d L~(-1)(95%CI:0.30~0.72)和6.53 mg·d L~(-1)(95%CI:1.96~11.11),但在女生中则没有观察到血清PFOS和PFOA水平与TC的相关性。趋势分析结果显示,随着儿童血清中PFOS和PFOA水平的增加,男生和女生血脂的TC、LDL和TG含量呈增高趋势。结论:台湾儿童血清PFOS和PFOA水平与血脂水平存在正相关,且在男生中观察到的效应强于女生。
[Abstract]:Objective: perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOAA) are widely used in industrial and living fields and can be detected in human and environmental media. Epidemiological studies in recent years have shown that exposure levels of PFOS and PFOA are correlated with serum lipids in children. The aim of this study was to study the gender difference between serum perfluorides and serum lipids in children. Methods: the correlation between serum total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and serum levels of PFOS and PFOA were analyzed in children in Taiwan. Results: the linear regression analysis showed that there was a significant correlation between serum PFOS- PFOA level and blood lipid level in male students. When the serum levels of ln-PFOS and ln-PFOA in male students increased by 1 ng mL / L), the levels of TC were increased by 0.51 mg / d / L ~ (95) CI: 0.30 ~ 0.72) and 6.53 mg / d / L ~ (95) CI: 1.96 / 11.11%, respectively. However, there was no correlation between serum PFOS and PFOA levels and TC in female students. The results of trend analysis showed that with the increase of serum levels of PFOS and PFOA in children, the levels of TCL-LDL and TG in serum of boys and girls showed an increasing trend. Conclusion: there is a positive correlation between serum PFOS and PFOA levels and blood lipid levels in Taiwanese children, and the effect is stronger in boys than in girls.
【作者单位】： 中山大学公共卫生学院预防医学系;中山大学中山医学院;广州市环境污染与健康风险评价重点实验室;国立台湾大学公共卫生学院预防医学研究所;
【基金】：国家自然科学基金项目(81472936,81172630) 广东省自然科学基金项目(2014A030313021)
【分类号】：R446.11
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本文编号：1880198