我院2012-2015年鲍曼不动杆菌分布及耐药性分析

发布时间：2018-05-20 13:29

本文选题：鲍曼不动杆菌 + 分布　；参考：《中国药房》2016年26期

【摘要】：目的:了解我院鲍曼不动杆菌的分布及耐药性,为合理使用抗菌药物提供参考。方法:收集我院2012年1月-2015年12月住院患者送检的各类临床标本,采用VITEK-2微生物分析仪对分离出的鲍曼不动杆菌进行鉴定及药敏试验;统计我院住院患者抗菌药物使用率及多重耐药、泛耐药鲍曼不动杆菌的检出情况,采用Pearson相关性分析考察两者的相关性。结果:我院2012-2015年共分离出鲍曼不动杆菌2 468株,主要来源于痰液标本(88.2%),主要分布于呼吸内科(47.0%)及重症监护病房(13.1%)。鲍曼不动杆菌对常见抗菌药物的耐药率总体较高,仅对替加环素敏感。我院各年度分别检出多重耐药鲍曼不动杆菌386(79.3%)、434(61.6%)、358(53.4%)和291(48.0%)株,泛耐药鲍曼不动杆菌336(69.0%)、385(54.7%)、331(49.3%)和256(42.2%)株。我院各年度抗菌药物使用率分别为56.7%、50.8%、45.0%和42.8%。多重耐药、泛耐药鲍曼不动杆菌在其总株数中的比例与抗菌药物使用率均呈正相关(r分别为0.987、0.981,P0.05)。结论:鲍曼不动杆菌是我院重要的院内感染病原菌,以引起呼吸系统感染为主;该菌的耐药现状不容乐观,替加环素可作为鲍曼不动杆菌感染治疗的首选药物之一。我院应继续严格控制抗菌药物的使用,减缓耐药菌株产生。
[Abstract]:Objective: to investigate the distribution and drug resistance of Acinetobacter baumannii in our hospital and to provide reference for rational use of antimicrobial agents. Methods: all kinds of clinical specimens were collected from our hospital from January 2012 to December 2015. The isolated Acinetobacter baumannii was identified and tested by VITEK-2 microbiological analyzer. The utilization rate of antimicrobial agents, multidrug resistance and pan-resistant Acinetobacter baumannii in inpatients in our hospital were analyzed. The correlation between them was investigated by Pearson correlation analysis. Results: a total of 2468 strains of Acinetobacter baumannii were isolated from our hospital from 2012 to 2015, mainly from sputum samples, mainly distributed in 47.0 in respiratory medicine department) and 13.1D in intensive care unit. Acinetobacter baumannii has high resistance to common antibiotics and is only sensitive to tegacycline. In each year, the strains of Acinetobacter baumannii 3860.79.3and Acinetobacter baumannii 3854.733149.3and 2560.42.2 were found in our hospital, respectively, and there were three strains of Acinetobacter baumannii (33654.733149.3d) and 2560.42.2). The utilization rate of antimicrobial agents in our hospital was 56.7% and 42.8% respectively. The proportion of Acinetobacter baumannii in the total number of strains and the utilization rate of antimicrobial agents were positively correlated with the rates of multidrug resistance and pan-resistant Acinetobacter baumannii, respectively. Conclusion: Acinetobacter baumannii is an important nosocomial infection pathogen in our hospital, which mainly causes respiratory infection, and the drug resistance of Acinetobacter baumannii is not optimistic. Tigicycline can be used as one of the first choice drugs in the treatment of Acinetobacter baumannii infection. Our hospital should continue to strictly control the use of antimicrobial agents and slow down the production of resistant strains.
【作者单位】：广州医科大学附属第三医院药学部;广州医科大学附属第三医院检验科;
【分类号】：R378

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