C反应蛋白与骨折手术术后输血不良反应发生率的相关性分析

发布时间：2018-05-20 16:38

本文选题：C反应蛋白 + 输血　；参考：《中国输血杂志》2016年06期

【摘要】：目的探讨C反应蛋白水平与骨折手术术后输血不良反应发生率的相关性。方法选择本院2012年7月—2015年1月,接受骨折手术治疗的103例患者为研究对象,按照术中输血方式不同将所有患者分为自体输血组51例和异体输血组52例。采用免疫荧光法测定输血前后的患者全血C反应蛋白水平,同时对2组患者的术中出血量、输血量及术后并发症情况进行比较,并对CRP水平与输血并发症进行相关分析。结果异体输血组患者输血后CRP水平为(18.9±7.2)mg/L,与输血前(8.2±6.4)mg/L相比较显著升高(t=4.251,P0.05);异体输血组术后3d测定全血CRP水平为(12.7±4.2)mg/L,与输血前比较,差异有统计学意义(t=-2.289,P0.05),但与输血后24 h内CRP水平相较仍有所下降(t=2.268,P0.05);自体输血组C反应蛋白水平在输血前后无统计学差异(F=0.084,P0.05)。异体输血与自体输血相比,输血后C反应蛋白水平具有明显差异(t=-3.545,P0.05;t=-3.545,P0.05)。51例自体输血组患者中共发生3例输血并发症(5.88%),52例异体输血组患者中并发症感染11例(21.15%),2组感染率比较,差异有统计学意义(χ2=5.113,P0.05),异体输血组并发症发生率较高,变化趋势与CRP水平一致,经单因素相关分析显示,异体输血组的CRP水平与输血并发症的发生率呈正相关(rs=0.569,tr=2.673,P0.05)。结论异体输血C反应蛋白水平与骨折手术术后并发症发生率呈正相关,C反应蛋白可能对骨折术后输血不良反应的发生发展具有一定的预测价值。
[Abstract]:Objective to investigate the correlation between C reactive protein level and the incidence of transfusion adverse reaction after fracture surgery. Methods from July 2012 to January 2015, 103 patients who received surgical treatment for fracture were divided into two groups: autotransfusion group (n = 51) and allogeneic transfusion group (n = 52). The whole blood C-reactive protein levels before and after blood transfusion were measured by immunofluorescence method. The intraoperative blood loss, blood transfusion volume and postoperative complications were compared between the two groups, and the correlation between the level of CRP and the complications of blood transfusion was analyzed. Results the CRP level in allogeneic blood transfusion group was 18.9 卤7.2 mg / L, which was significantly higher than that in pre-transfusion group (8.2 卤6.4)mg/L), and the whole blood CRP level in allogeneic blood transfusion group was 12.7 卤4.2 mg / L on the 3rd day after operation, compared with that before blood transfusion. The difference was statistically significant (P 0.05), but the level of CRP was still lower than that within 24 h after blood transfusion, while the level of C-reactive protein in autologous transfusion group had no statistical difference before and after blood transfusion. Compared with autologous blood transfusion, the level of C-reactive protein in allogeneic blood transfusion was significantly different from that in autologous blood transfusion. There were significant differences in C-reactive protein level between two groups. Among 51 cases of autotransfusion group, there were 3 cases of blood transfusion complications and 52 cases of allogeneic blood transfusion group. The infection rate of 11 cases of complication infection was 21.1555%. The difference was statistically significant (蠂 2 / 5.113 / P 0.05). The incidence of complications in allogeneic blood transfusion group was higher, and the change trend was consistent with the level of CRP. The single factor correlation analysis showed that there was a positive correlation between the CRP level of allogeneic blood transfusion group and the incidence rate of transfusion complications. Conclusion the level of C-reactive protein in allogeneic blood transfusion is positively correlated with the incidence of postoperative complications of fracture surgery. It may have some predictive value for the occurrence and development of adverse reaction of transfusion after fracture.
【作者单位】：哈尔滨医科大学附属第一医院输血科;
【分类号】：R457.13;R687.3

【相似文献】