2014年某三甲医院老年病人细菌耐药性监测

发布时间：2018-05-25 18:40

本文选题：细菌耐药性监测 + 耐药率　；参考：《现代预防医学》2016年01期

【摘要】：目的了解2014年某三甲医院老年病人临床分离菌对常见抗菌药物的耐药性。方法使用自动化细菌鉴定仪VITEK 2-COMPACT对分离菌株的耐药性进行鉴定,药敏结果按CLSI 2014年版标准判断。结果临床分离的2 167株细菌中,G-菌占69.4%,G+菌占30.6%。耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林的凝固酶阴性葡萄球菌(MRSCNS)的检出率分别为29.5%、85.8%。葡萄球菌属中甲氧西林耐药株对所测试抗菌药物的耐药率显著高于甲氧西林敏感株,未发现对万古霉素和利奈唑胺耐药的菌株。对大部分所测抗菌药物,屎肠球菌的耐药率高于粪肠球菌。在屎肠球菌中发现9株万古霉素耐药株,在粪肠球菌中发现2株利奈唑胺耐药株。青霉素耐药的非脑膜炎肺炎链球菌占6.2%,非脑膜炎肺炎链球菌对红霉素耐药率为95.4%。检出53.8%的大肠埃希菌和28.2%的肺炎克雷伯菌产超广谱β-内酰胺酶。鲍曼不动杆菌对亚胺培南和美罗培南的耐药率分别为53.9%、52.9%,铜绿假单胞菌对上述两种药物的耐药率分别为33.9%、28.0%。结论在大于65岁患者中分离的细菌耐药情况应引起足够重视,加强对医院感染控制和指导抗生素合理使用。
[Abstract]:Objective to investigate the antimicrobial resistance of clinical isolates of geriatric patients in a third class hospital in 2014. Methods VITEK 2-COMPACT was used to identify the drug resistance of the isolated strains, and the drug sensitivity was judged according to the CLSI 2014 standard. Results among the 2 167 strains of bacteria isolated clinically, 69.4% were G- bacteria and 30.6% were GG bacteria. The detectable rates of MRSAs and MRSCNSs of methicillin-resistant staphylococcus aureus and methicillin-resistant coagulase negative staphylococci were 29.5and 85.8, respectively. The resistance rate of methicillin-resistant strains to tested antibiotics was significantly higher than that of methicillin-sensitive strains, and no vancomycin and linazolamide resistant strains were found. The drug resistance rate of Enterococcus faecium was higher than that of Enterococcus faecalis. Nine vancomycin resistant strains were found in Enterococcus faecium and two linazolamide resistant strains were found in Enterococcus faecalis. Penicillin resistant streptococcus pneumoniae accounted for 6.2% and non-meningococcal streptococcus pneumoniae resistant rate to erythromycin was 95.4%. 53.8% of Escherichia coli and 28.2% of Klebsiella pneumoniae produced extended-spectrum 尾 -lactamases. The resistance rates of Acinetobacter baumannii to imipenem and meropenem were 53.9 and 52.9, respectively, and those of Pseudomonas aeruginosa to these two drugs were 33.9and 28.0, respectively. Conclusion enough attention should be paid to the drug resistance of bacteria isolated in patients over 65 years old, to strengthen the control of nosocomial infection and to guide the rational use of antibiotics.
【作者单位】：四川大学华西医院实验医学科;四川省医学科学院·四川省人民医院检验科;
【分类号】：R446.5

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