上海地区幽门螺杆菌的检出率及耐药性分析

发布时间：2018-05-25 23:21

本文选题：幽门螺杆菌 + 阳性检出率　；参考：《中国感染与化疗杂志》2016年03期

【摘要】：目的了解幽门螺杆菌的阳性检出率及其影响因素,分析上海2所医院幽门螺杆菌临床分离菌株对一线治疗幽门螺杆菌抗菌药物的耐药性,为临床幽门螺杆菌根治提供用药依据。方法收集上海2所医院2013年9月—2015年1月临床胃组织活检样本,进行幽门螺杆菌分离培养和鉴定;采用E试验法对131株幽门螺杆菌临床菌株分别进行4种治疗幽门螺杆菌的一线抗菌药物克拉霉素、甲硝唑、阿莫西林和四环素的体外药敏试验。结果共收集955例胃组织活检样本,分离出幽门螺杆菌248株,检出率为26.0%。幽门螺杆菌对克拉霉素、甲硝唑、四环素和阿莫西林的耐药率分别为14.5%、64.1%、0和0.8%,对上述药物中的2种同时耐药占10.7%(14/131),其中92.8%(13/14)为克拉霉素和甲硝唑同时耐药。结论幽门螺杆菌阳性检出率较以前报道的阳性携带率低,且与性别、年龄与疾病类型等因素相关,而耐药率则与之无明显相关性。幽门螺杆菌的临床治疗应根据体外药敏结果进行个体化用药。
[Abstract]:Objective to investigate the positive rate of Helicobacter pylori and its influencing factors, to analyze the drug resistance of clinical isolates of Helicobacter pylori to first-line treatment of Helicobacter pylori, and to provide evidence for the radical therapy of Helicobacter pylori. Methods Clinical gastric tissue biopsy samples were collected from 2 hospitals in Shanghai from September 2013 to January 2015. Helicobacter pylori was isolated and identified. Four first-line antimicrobial agents clarithromycin, metronidazole, amoxicillin and tetracycline were tested on 131 clinical strains of Helicobacter pylori by E test. Results 248 strains of Helicobacter pylori were isolated from 955 cases of gastric biopsy and the positive rate was 26.0%. The resistance rates of Helicobacter pylori to clarithromycin, metronidazole, tetracycline and amoxicillin were 14.54.1and 0.8, respectively. Conclusion the positive rate of Helicobacter pylori is lower than the reported positive rate, and it is related to sex, age and disease type, but the drug resistance rate is not. The clinical treatment of Helicobacter pylori should be individualized according to the drug sensitivity in vitro.
【作者单位】：复旦大学附属华东医院检验科;复旦大学附属华东医院消化内科;同济大学附属同济医院消化内科;
【基金】：上海市卫生局重点课题基金(20134008) 上海申康医院发展中心新兴前沿技术联合攻关项目基金(SHDC12013123) 上海市科委自然科学基金(14ZR1413100);上海市科委引导项目基金(14411962800)
【分类号】：R446.5

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