某医院临床分离金黄色葡萄球菌的分布及其耐药性变迁

发布时间：2018-05-27 16:06

本文选题：金黄色葡萄球菌 + 抗菌药物　；参考：《中国消毒学杂志》2016年12期

【摘要】：目的了解医院临床标本分离金黄色葡萄球菌的分布及其耐药性变化情况,为临床合理用药提供依据。方法采用细菌分离鉴定和药敏试验方法,对某医院住院患者送检病原学标本检出金黄色葡萄球菌分布及其耐药性进行分析。结果该医院连续3年从住院患者送检标本中共分离出金黄色葡萄球菌434株,其中耐甲氧西林的金黄色葡萄球菌(MRSA)82株,占18.89%。在各类标本中以痰液分离率最高,其次是分泌物和脓液。临床分离的金黄色葡萄球菌主要分布在耳鼻喉科,其次是重症监护室(ICU)和神经外科。临床分离金黄色葡萄球菌对青霉素、氨苄西林、红霉素耐药率较高,未发现耐万古霉素菌株,MRSA的耐药率明显高于甲氧西林敏感(MSSA)菌株。结论该医院在连续3年内金黄色葡萄球菌的检出率和耐药性均无明显变化,这主要得益于严格执行感染防控措施和合理使用抗菌药物。
[Abstract]:Objective to investigate the distribution and drug resistance of Staphylococcus aureus isolated from clinical specimens in hospital and to provide evidence for rational drug use. Methods the distribution and drug resistance of Staphylococcus aureus were analyzed by bacteria isolation and drug sensitivity test. Results A total of 434 strains of Staphylococcus aureus were isolated from hospitalized patients for 3 consecutive years, of which 82 strains (18.89%) were methicillin-resistant Staphylococcus aureus. Among all kinds of specimens, sputum separation rate was the highest, followed by secretion and pus. Staphylococcus aureus isolated clinically was mainly distributed in otolaryngology, followed by ICU (intensive care unit) and neurosurgery. The resistant rate of Staphylococcus aureus to penicillin, ampicillin and erythromycin was higher than that of methicillin-sensitive strains. No vancomycin resistant strains were found to be resistant to MRSA. Conclusion the detection rate and drug resistance of Staphylococcus aureus in this hospital have not changed significantly in the past 3 years, which is mainly due to the strict implementation of infection prevention and control measures and rational use of antimicrobial agents.
【作者单位】：锦州医科大学附属第一医院;
【分类号】：R446.5

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