冷沉淀对感染患者Slit2蛋白表达的影响

发布时间：2018-06-10 08:38

  本文选题：冷沉淀 + 感染　； 参考：《中国输血杂志》2016年05期

【摘要】：目的了解冷沉淀输注对感染患者Slit2蛋白表达的影响。方法随机将61名感染患者分为治疗实验组:31名患者使用常规抗感染药物+冷沉淀输注治疗;治疗对照组:30名患者单纯使用常规抗感染药物治疗;使用ELISA方法检测30名健康人以及2组感染患者在治疗前后的12-24 h的新鲜血浆标本中Slit2蛋白水平;观察健康人与2组感染患者血浆中的Slit2蛋白水平,比较2组感染患者在治疗前后血浆Slit2蛋白水平及相关临床指标的变化。结果治疗后实验组、对照组感染患者和健康人血浆Slit2蛋白水平(ng/m L)分别为2.432 vs 3.644 vs 1.382(P0.05);实验组感染患者的治疗前后的血浆Slit2蛋白水平(ng/m L)为3.117 vs 2.432,WBC(×10~9/L)为10.31±6.00 vs 9.32±5.66,分类计数(×10~9/L)为7.53±5.34 vs 6.80±4.51,PT(s)为20.33±5.93 vs 20.32±5.73(P0.05),APTT(s)为51.43±13.47 vs 51.66±16.43;对照组患者在治疗前后血浆Slit2蛋白水平及相关临床指标无明显变化(P0.05)。结论血浆Slit2蛋白对评价感染性疾病治疗疗效具有潜在的参考价值;输注冷沉淀可以降低感染患者Slit2蛋白的表达,可能对辅助治疗感染性疾病有效。
[Abstract]:Objective to investigate the effect of cryoprecipitation on the expression of Slit2 protein in infected patients. Methods Sixty-one infected patients were randomly divided into experimental group (n = 31) and control group (n = 30). The levels of Slit2 protein in fresh plasma samples of 30 healthy people and 2 groups of infected patients before and after treatment were detected by Elisa, and the levels of Slit2 protein in plasma of healthy persons and infected patients were observed. The changes of plasma Slit2 protein and related clinical indexes were compared before and after treatment. Results after treatment, the experimental group, The plasma Slit2 protein level in the control group was 2.432 vs 3.644 vs 1.382 g / mL, respectively, and the plasma Slit2 protein level was 3.117 vs 2.432 WBBC (脳 10 9 / L), and the classification count (脳 10 9 L) was 7.53 卤5.34 vs 6.80 卤4.51 卤5.93 vs 20.33 卤5.93 in the experimental group before and after treatment, respectively, and the mean Slit2 protein level was 10.31 卤6.00 vs 9.32 卤5.66 in the control group and in the control group, respectively. The mean plasma Slit2 protein level was 20.33 卤5.93 before and after treatment in the patients with infection in the experimental group. The mean Slit2 protein level was 10.31 卤6.00 vs 9.32 卤5.66 in the control group and in the control group, respectively. The plasma Slit2 protein level and related clinical indexes in the control group were not significantly changed before and after the treatment. The results showed that the plasma Slit2 protein level was 51.43 卤13.47 vs 51.66 卤16.43.The plasma Slit2 protein level and the related clinical indexes were not significantly changed in the control group before and after treatment. Conclusion Plasma Slit2 protein has potential reference value in evaluating the therapeutic efficacy of infectious diseases, and cryoprecipitation can reduce the expression of Slit2 protein in infected patients, which may be effective in adjuvant treatment of infectious diseases.
【作者单位】： 中南大学湘雅医院输血科;
【分类号】：R457.1

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