脓毒症的病理生理机制研究进展

发布时间：2018-06-21 21:39

本文选题：脓毒症 + 炎症反应　；参考：《中华医院感染学杂志》2016年08期

【摘要】：脓毒症是由严重感染引起的综合征,机体对感染的免疫反应十分复杂,通常情况下,病原体入侵机体,引起机体细胞及体液免疫反应,发生促炎和抗炎反应,若二者不能平衡,引起若干介质释放,发生一系列病理生理变化,导致脓毒症,甚至引起多器官功能障碍;该综述简述了脓毒症的定义,并从宿主反应、先天免疫、凝血异常、炎症反应、凝血与炎症网络、免疫抑制、器官功能障碍、基因多态性等对脓毒症的病理生理机制进展,以期进一步深入理解脓毒症的病理生理机制,为临床治疗奠定理论基础,指导未来从整体、器官、细胞、分子、基因水平进行多层次综合性研究,深入探索和认识脓毒症的确切发病机制,防止脓毒症发生发展,最终提高人类危重症的救治水平。
[Abstract]:Sepsis is a syndrome caused by severe infection. The immune response of the body to infection is very complicated. Usually, pathogens invade the body, causing cellular and humoral immune responses, and producing pro-inflammatory and anti-inflammatory reactions, if the two cannot be balanced. It causes a series of pathophysiological changes, leading to sepsis and even multiple organ dysfunction. This review summarizes the definition of sepsis, and describes the host response, innate immunity, abnormal coagulation, inflammatory response. Advances in pathophysiological mechanisms of sepsis, such as coagulation and inflammatory network, immunosuppression, organ dysfunction, gene polymorphism, etc., in order to further understand the pathophysiological mechanisms of sepsis and lay a theoretical foundation for clinical treatment. To guide the future from the overall, organ, cell, molecular, gene level of multi-level comprehensive research, in-depth exploration and understanding of the exact pathogenesis of sepsis, to prevent the occurrence and development of sepsis, and ultimately improve the level of human critical care.
【作者单位】：内蒙古医科大学研究生学院临床系;内蒙古医科大学附属医院血液内科;内蒙古医科大学附属医院检验科;
【基金】：内蒙古自治区科研基金资助项目(2013-9)
【分类号】：R459.7

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