尿液作为新型生物标志物来源的探索

发布时间：2018-06-29 00:14

本文选题：变化 + 稳态机制　；参考：《生物化学与生物物理进展》2016年11期

【摘要】：机体各种变化是生物标志物研究的核心内容.因为机体固有的稳态调控机制,在血液中早期产生的变化容易被清除.而在尿液中不存在稳态调控机制,允许容纳更多的变化因素存在.尤其在疾病发生的早期阶段,从尿液中更有可能发现新型的早期生物标志物.在尿液生物标志物研究中,亦应当考虑药物的影响.使用尿液生物标志物研究路线图,能够有效规避各种影响因素对于尿液生物标志物研究的干扰;同时,结合膜处理新技术,有利于经济、高效地大规模收集尿液样本,促进尿液生物标志物的大规模研究.另外,本文介绍了最容易在尿液中体现出变化的肾脏疾病生物标志物的研究进展.尿液生物标志物的研究,将赋予人类在疾病预防、诊断、治疗及预后监测等诸多方面实现更多进步的可能性.
[Abstract]:Various changes of organism are the core contents of biomarker research. Because of the homeostasis inherent in the body, changes that occur early in the blood are easily removed. However, there is no stable regulation mechanism in urine, allowing for the presence of more variable factors. New early biomarkers are more likely to be found in urine, especially in the early stages of disease. The effects of drugs should also be considered in the study of urine biomarkers. The use of a road map for urine biomarker research can effectively avoid the interference of various influencing factors in the research of urine biomarkers; at the same time, combining with the new technology of membrane processing, it is advantageous to collect urine samples on an economical and efficient scale. To promote large-scale research on urine biomarkers. In addition, this article introduces the research progress of renal disease biomarkers that are most likely to manifest changes in urine. The study of urine biomarkers will give us the possibility to make more progress in disease prevention, diagnosis, treatment and prognosis monitoring.
【作者单位】：北京师范大学生命科学学院北京市基因工程药物与生物技术重点实验室;
【基金】：国家重点基础研究发展计划(2012CB517606,2013CB530805)资助项目~~
【分类号】：R446.12

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