2009～2014年重庆地区儿童感染阴沟肠杆菌的临床分布及耐药性分析

发布时间：2018-07-02 10:39

本文选题：阴沟肠杆菌 + 耐药性　；参考：《重庆医学》2016年35期

【摘要】：目的了解重庆地区儿童2009~2014年感染阴沟肠杆菌的临床分布特征及耐药性,为合理应用抗菌药物和预防控制医院感染提供依据。方法分析2009~2014年检出的阴沟肠杆菌对15种抗菌药物的耐药性,采用BD Phoenix 100全自动微生物鉴定/药敏系统,以最小抑菌浓度(MIC)结合K-B纸片扩散法进行药敏试验,按美国临床实验室标准化协会(CLSI)标准判断结果。结果共分离阴沟肠杆菌3 384株,检出率为4.18%;以呼吸道标本多见,占83.04%。阴沟肠杆菌对美洛培南和亚胺培南的耐药率最低,分别为0.88%和0.94%;对左氧氟沙星、环丙沙星、哌拉西林/他唑巴坦的耐药率分别为4.38%、5.17%,26.49%。2009~2014年阴沟肠杆菌对15种抗菌药物的耐药率比较,差异均有统计学意义(P0.05)。共检出产超广谱β-内酰胺酶(ESBLs)阴沟肠杆菌87株,占2.57%。新生儿病房和呼吸病房检出阴沟肠杆菌的构成比高于其他病区,分别为26.92%、24.32%。结论阴沟肠杆菌的耐药性呈上升趋势,新生儿科与呼吸科是预防控制的重点科室。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of Enterobacter cloacae infection in children in Chongqing from 2009 to 2014, and to provide evidence for rational use of antimicrobial agents and prevention and control of nosocomial infection. Methods the drug resistance of Enterobacter cloacae to 15 antimicrobial agents was analyzed in 2009 and 2014. BD Phoenix 100 automatic microbial identification / drug sensitivity system was used to test the drug sensitivity of Enterobacter cloacae by minimal inhibitory concentration (MIC) combined with K-B disk diffusion. The results were judged by the American Association for Clinical Laboratory Standardization (CLSI). Results A total of 3 384 strains of Enterobacter cloacae were isolated, the positive rate was 4.18, and the respiratory tract was the most common, accounting for 83.04. The resistance rates of Enterobacter cloacae to melopenem and imipenem were 0.88% and 0.94%, respectively. The resistance rates to levofloxacin, ciprofloxacin, piperacillin / tazobactam were 4.38%, 5.17% and 26.49%, respectively, and the resistance rates of Enterobacter cloacae to 15 antimicrobial agents from 2009 to 2014 were compared. The difference was statistically significant (P0.05). Extended-spectrum 尾 -lactamases (ESBLs) were isolated from 87 strains of Enterobacter cloacae, accounting for 2.57 strains. The composition ratio of Enterobacter cloacae detected in neonatal ward and respiratory ward was higher than that in other wards, which were 26.92 and 24.32 respectively. Conclusion the drug resistance of Enterobacter cloacae is on the rise.
【作者单位】：重庆医科大学附属儿童医院检验科/儿童发育疾病研究教育部重点实验室/儿科学重庆市重点实验室/重庆市儿童发育重大疾病诊治与预防国际科技合作基地;
【分类号】：R446.5;R725.1

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