他汀类药物在老年重症监护室脓毒症患者中的应用价值及作用机制

发布时间：2018-07-11 12:37

本文选题：他汀类药物 + 脓毒症　；参考：《中国老年学杂志》2016年22期

【摘要】：目的观察他汀类药物在老年重症监护室(ICU)脓毒症患者中的应用价值及作用机制。方法回顾性分析98例老年ICU脓毒症患者治疗和随访资料,并按照是否服用他汀类药物分为服用组(56例)和未服用组(42例)。对比ICU滞留时间、机械通气天数、连续肾脏替代治疗(CRRT)时间,并统计治疗前、治疗7 d后C反应蛋白(CRP)、白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、超氧化物歧化酶(SOD)水平变化,并统计治疗28 d内存活率。结果服用组ICU滞留时间、机械通气天数、CRRT时间均明显少于未服用组(P0.05);治疗前两组CRP、IL-6、TNF-α、SOD水平均无显著差异(P0.05),7 d后两组SOD均较治疗前显著升高(P0.05),其他因子水平均较治疗前显著降低(P0.05),且7 d后服用组CRP、IL-6、TNF-α、SOD与未服用组间均存在显著差异(P0.05);服用组28 d存活率为85.71%,远高于未服用组(66.67%,P0.05)。结论他汀类药物在老年ICU脓毒症患者中应用可显著缩短治疗时间、提高28 d存活率,与减轻炎症反应、提升氧自由基清除能力有关。
[Abstract]:Objective to observe the application value and mechanism of statins in geriatric intensive care unit (ICU) patients with sepsis. Methods the data of 98 patients with sepsis in elderly ICU were analyzed retrospectively. According to whether to take statins or not, they were divided into two groups: taking group (n = 56) and non-taking group (n = 42). The retention time of ICU, the days of mechanical ventilation, the time of continuous renal replacement therapy (CRRT), and the changes of C-reactive protein (CRP), interleukin (IL) -6, tumor necrosis factor (TNF)-伪 and superoxide dismutase (SOD) before and 7 days after treatment were compared. The survival rate within 28 days was counted. Results the retention time of ICU in the taking group, The CRRT time of mechanical ventilation was significantly shorter than that of the control group (P0.05), and there was no significant difference between the two groups before and after treatment (P0.05). After 7 days of treatment, the level of SOD in the two groups was significantly higher than that before treatment (P0.05), and the level of other factors was significantly lower than that before treatment (P0.05), and the level of other factors was significantly lower than that before treatment (P0.05), and after 7 days of treatment, the level of SOD in the two groups was significantly higher than that before treatment (P0.05). There was significant difference between the two groups (P0.05), and the 28d survival rate was 85.71, which was much higher than that in the control group (66.67g / kg, P0.05). Conclusion the application of statins in geriatric ICU patients with sepsis can significantly shorten the treatment time and increase the survival rate of 28 days, which is related to reducing inflammation and improving the ability of scavenging oxygen free radicals.
【作者单位】：广州医科大学附属深圳沙井医院;
【基金】：深圳市宝安区科技创新局项目(深宝科2015195号)
【分类号】：R459.7

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