亚低温疗法对心肺复苏后患者神经功能的影响

发布时间：2018-07-17 05:44

【摘要】：目的探讨亚低温疗法对心肺复苏后患者神经功能的影响。方法采用单中心前瞻性随机对照的临床研究方法,选取2014年9月—2015年12月潍坊医学院附属医院抢救的心搏骤停进行心肺复苏后自主循环恢复的患者为研究对象,按随机数字表法将患者分为对照组和试验组。自主循环恢复后,对照组给予常规头部冰袋降温治疗,试验组患者快速2 h体温降至33~35℃后,应用亚低温治疗仪维持亚低温(33~35 V)治疗。记录复苏后0、2、24、48、72 h患者直肠温度、血清干扰素α(TNF-α)和白介素6(IL-6)表达水平及格拉斯哥昏迷量表(GCS)评分。结果共45例患者纳入本研究,其中试验组23例,对照组22例。复苏后0 h,两组直肠温度、TNF-α和IL-6表达水平比较,差异均无统计学意义(P0.05);复苏后2、24、48、72 h,试验组直肠温度、TNF-α和IL-6表达水平均低于对照组,GCS评分均高于对照组(P0.05)。对照组和试验组TNF-α、IL-6表达水平与GCS评分均呈正相关(=0.683、0.969,P0.05;=0.815、0.985,P0.05)。结论心肺复苏后患者应用亚低温疗法可以降低血清TNF-α及IL-6表达水平,减轻组织损伤,增高GCS评分,改善患者神经功能预后。
[Abstract]:Objective to investigate the effect of mild hypothermia therapy on neurological function after cardiopulmonary resuscitation (CPR). Methods A single center prospective randomized controlled clinical study was conducted to study the patients with cardiac arrest after cardiopulmonary resuscitation (CPR) from September 2014 to December 2015 in the affiliated Hospital of Weifang Medical College. Patients were divided into control group and trial group according to random digital table. After the recovery of spontaneous circulation, the control group was treated with conventional head ice bag cooling. The patients in the experimental group were treated with mild hypothermia (335V) after their body temperature dropped to 33 鈩，

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