呼吸道感染儿童九项呼吸道病原体IgM抗体结果分析

发布时间：2018-07-17 06:45

【摘要】：目的探讨九项呼吸道病原体Ig M抗体在呼吸道感染儿童中的流行现状,为临床有效防治提供依据。方法选取呼吸道感染住院患儿1 454例,间接免疫荧光法检测嗜肺军团菌血清1型(LP1)、肺炎支原体(MP)、Q热立克次体(COX)、肺炎衣原体(CPn)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)、乙型流感病毒(INFB)和副流感病毒1、2、3型(PIVs)Ig M抗体,分析其阳性率及季节性变化。结果在1 454例患儿中,共检出呼吸道病原体Ig M抗体阳性729例,阳性率50.14%;MP阳性率最高,其次为INFB、ADV、RSV、PIVs;MP和INFB在女性患儿阳性率显著高于男性患儿(P0.01);不同年龄段患儿呼吸道病原体Ig M抗体阳性率不同,3~7岁患儿阳性率最高,其中MP和INFB阳性率分别为55.70%和33.76%,显著高于其他年龄段患儿(P0.01);MP、PIVs、RSV、INFB、LP1和ADV在5月份的阳性率最高,分别是59.49%、14.56%、13.29%、43.67%、5.06%和30.38%。结论儿童呼吸道病原体主要是MP和INFB,女孩阳性率显著高于男孩,3~7岁年龄段儿童为呼吸道病原体感染的高发人群。
[Abstract]:Objective to investigate the prevalence of 9 respiratory pathogens IgG M antibody in children with respiratory tract infection and to provide evidence for effective prevention and treatment. Methods 1 454 hospitalized children with respiratory tract infection were selected. Indirect immunofluorescence assay was used to detect IgG M antibodies of Legionella pneumophila serotype 1 (LP1), mycoplasma pneumoniae (MP), Chlamydia pneumoniae (CPN), adenovirus (ADV), respiratory syncytial virus (RSV), influenza A virus (INFA), influenza B virus (INFB) and parainfluenza virus type 1 (PIVs). The positive rate and seasonal variation were analyzed. Results among the 1 454 children, 729 cases were positive for IgM antibody in respiratory tract, the positive rate was 50.14% and the positive rate of MP was the highest. The positive rates of PIVsMMP and INFB were significantly higher in females than in males (P0.01), and the positive rates of IgM antibodies in respiratory tract pathogens were the highest in children of different ages. The positive rates of MP and INFB were 55.70% and 33.766.The positive rates of MP and INFB were 55.70% and 33.76%, respectively, which were significantly higher than those of other age groups (P0.01). Conclusion MP and INFB are the main pathogens in respiratory tract of children, and the positive rate of girls is significantly higher than that of boys aged 37 years.
【作者单位】：安徽医科大学第一附属医院检验科;安徽医科大学第一附属医院ICU;安徽医科大学第一附属医院风湿免疫科;
【基金】：国家自然基金(编号:30801088,81201488,81571572) 卫生部应用研究项目“高通量ELISA检测系统化、标准化系列研究”(编号:28-1-50)
【分类号】：R725.6;R446.6

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