microRNAs在脓毒症引起的炎症反应中的调控机制

发布时间：2018-07-17 07:24

【摘要】：近年来脓毒症的发病率及病死率逐渐增高,成为临床上危重患者最常见的并发症及主要死亡原因,为全球各国医疗保健体系中最昂贵支出的病种之一。因此,人们开始越来越关注脓毒症的病理发展机制,以期能够早期诊断并及时治疗脓毒症。脓毒症指的是病原微生物侵入机体后,机体内出现大量的炎症介质释放,并且破坏了机体内抗炎反应与促炎反应的平衡,导致全身各个器官组织出现炎症反应综合征,最终发展为多器官功能衰竭。现阶段并没有切实有效的治疗措施来治疗脓毒症,并且抗炎治疗的效果十分不理想。microRNAs的发现及时补充了在转录后水平对靶基因mRNA进行精确有效的调节,以便为有效防治脓毒症提供一个全新的靶点。因此,本文作者对microRNAs在脓毒症炎症反应过程中的发生机制进行了综述。
[Abstract]:In recent years, the morbidity and mortality of sepsis have gradually increased, which has become the most common complication and main cause of death of critically ill patients. It is one of the most expensive diseases in the medical care system of the world. Therefore, people begin to pay more and more attention to the pathophysiological mechanism of sepsis in order to diagnose and treat sepsis in time. Sepsis refers to the release of a large number of inflammatory mediators in the body after the invasion of pathogenic microorganisms, and the disruption of the balance between anti-inflammatory and pro-inflammatory reactions in the body, leading to inflammatory response syndrome in all organs and tissues of the whole body. Eventually, it develops into multiple organ failure. At this stage, there are no effective treatment measures to treat sepsis, and the effect of anti-inflammatory therapy is not ideal. The discovery of microRNAs complements the accurate and effective regulation of target gene mRNA at post-transcriptional level. In order to provide a new target for the effective prevention and treatment of sepsis. Therefore, the mechanism of microRNAs in the inflammatory response of sepsis was reviewed.
【作者单位】：中南大学湘雅二医院麻醉科/中南大学麻醉研究所;
【基金】：国家自然科学基金资助项目(81201448)
【分类号】：R459.7

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