MR钆对比剂全身性不良反应的研究:18540例连续病例分析

发布时间：2018-07-18 11:12

【摘要】：目的:探讨静脉注射钆对比剂的全身性不良反应发生情况。方法:利用对比剂安全信息系统的数据,搜集行MR增强检查的18540例连续患者的病例资料,对注射钆对比剂后的全身性反应进行统计,分析不良事件出现时间及其与对比剂的相关性,分为急性不良反应(1h)、迟发性不良反应(1h~1w)和晚迟发不良反应(1w)三类,进一步将不良反应分为轻、中、重度三类,分别进行统计分析。结果:18540例共发生全身性不良反应24例,总发生率为0.13%。急性不良反应16例(0.09%),其中轻度9例、中度4例、重度3例。迟发性不良反应8例(0.04%),其中轻度6例、中度2例。无晚迟发不良反应。结论:MR增强检查注射钆对比剂发生全身性不良反应的概率很低,但有发生急性重度不良反应的可能,应予以关注。
[Abstract]:Objective: to investigate the occurrence of systemic adverse reactions of intravenous gadolinium contrast agent. Methods: using the data of contrast agent safety information system, the data of 18540 consecutive patients with Mr enhancement were collected, and the systemic response after gadolinium contrast injection was statistically analyzed. The occurrence time of adverse events and their correlation with contrast agents were analyzed and divided into three categories: acute adverse reactions (1h), delayed adverse reactions (1h~1w) and late delayed adverse reactions (1w). The adverse reactions were further divided into three categories: mild, moderate and severe. Statistical analysis was carried out respectively. Results there were 24 cases of systemic adverse reactions in 18540 cases, the total incidence was 0.13%. There were 16 cases (0.09%) of acute adverse reactions, including mild 9 cases, moderate 4 cases, severe 3 cases. Delayed adverse reactions were found in 8 cases (0.04%), including mild 6 cases and moderate 2 cases. There were no late adverse reactions. Conclusion the probability of systemic adverse reactions in contrast-gadolinium injection is very low, but the possibility of acute and severe adverse reactions should be paid attention to.
【作者单位】：北京大学第一医院医学影像科;
【分类号】：R445.2

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