2008-2014年南昌某医院金黄色葡萄球菌耐药谱及变化趋势

发布时间：2018-07-18 15:55

【摘要】：目的了解2008-2014年医院金黄色葡萄球菌耐药变化趋势及MRSA感染下降的原因,为更加有效地控制及预防MRSA感染提供依据。方法利用院内监测数据分析2008-2014年金黄色葡萄球菌的耐药状况、科室来源、分离部位及重点科室MRSA感染率的变迁及原因。结果 (1)2008-2014年共计分离到2525株金黄色葡萄球菌,主要来源科室包括呼吸科、烧伤科、脑外科、骨科、ICU和急诊科。(2)青霉素、苯唑西林、氨苄西林/舒巴坦、亚胺培南、四环素、红霉素、利福平、林可霉素、庆大霉素、环丙沙星、莫西沙星的耐药呈下降趋势;复方新诺明耐药小幅上升;而喹奴普汀/达福普汀、利奈唑烷、万古霉素耐药率维持2%以下。(3)烧伤科、ICU的MRSA感染率一直维持高水平;骨科和呼吸科呈明显下降。结论 2008-2014年南昌某医院金黄色葡萄球菌耐药呈下降趋势,但不同科室MRSA感染率改变趋势不同。应保持目前的抗生素管理模式,对高水平MRSA感染科室制定更加有效的管理措施,切实降低MRSA感染率。
[Abstract]:Objective to investigate the trend of drug resistance of Staphylococcus aureus in hospital from 2008 to 2014 and the reasons for the decrease of MRSA infection so as to provide evidence for more effective control and prevention of MRSA infection. Methods the drug resistance of Staphylococcus aureus from 2008 to 2014 was analyzed with the in-hospital monitoring data. The changes and causes of MRSA infection rate in departments, isolated sites and key departments were analyzed. Results (1) A total of 2525 strains of Staphylococcus aureus were isolated from 2008 to 2014, including respiratory department, burn department, brain surgery department, orthopedic ICU and emergency department. (2) penicillin, oxacillin, ampicillin / sulbactam, imipenem, tetracycline. Erythromycin, rifampicin, lincomycin, gentamicin, ciprofloxacin, moxifloxacin showed a downward trend; compound sulfamine showed a slight increase in drug resistance; and quinoptin / dafoptin, linazolidine, The rate of vancomycin resistance remained below 2%. (3) MRSA infection rate in ICU of burn department maintained a high level, while orthopedic and respiratory departments showed a significant decrease. Conclusion the drug resistance of Staphylococcus aureus decreased in a hospital in Nanchang from 2008 to 2014, but the infection rate of MRSA was different in different departments. The current antibiotic management mode should be maintained, and more effective management measures should be established for high level MRSA infection departments to reduce MRSA infection rate.
【作者单位】：南昌大学第一附属医院;南昌大学公共卫生学院;
【分类号】：R446.5

【相似文献】