肠球菌在各类感染标本中分布及其耐药情况分析

发布时间：2018-07-24 18:27

【摘要】：目的分析肠球菌在各类感染标本中分布与常用药物敏感性情况。方法收集江汉大学附属笫三医院武汉市黄陂区人民医院2013年6月至2015年6月临床标本分离出的肠球菌属366株。用法国梅里埃生物鉴定系统进行菌种鉴定,并用扩散法进行耐药监测,用WHONET 5.6软件进行统计分析。结果 366株肠球菌主要分布在泌尿标本与伤口分泌物标本中,粪肠球菌为97株(26.50%)、屎肠球菌为137株(37.43%)、其他肠球菌为26株(7.10%)、未鉴定到菌种的为106株(28.96%)。肠球菌属对常见抗生素呈多重性耐药,对万古霉素的敏感性/耐药性为95.90%/3.00%,对替考拉宁的敏感性/耐药性为97.50%/1.60%,对利奈唑胺的敏感性/耐药性为99.70%/0.30%,均有较高的敏感性。结论肠球菌属细菌耐药较严重,不同菌种耐药性也有所差异,感染部位常见于泌尿系统,临床医师在治疗肠球菌感染时,应依据耐药特性和药敏试验结果合理选用抗菌药物,加强对细菌耐药性监测,以防止多重耐药菌的传播。
[Abstract]:Objective to analyze the distribution of Enterococcus in various infection specimens and the sensitivity of common drugs. Methods 366 strains of Enterococcus isolated from Huangpi District people's Hospital of Wuhan City from June 2013 to June 2015 were collected. The strain identification was carried out with the French Merier biometric identification system, the drug resistance was monitored by diffusion method, and the statistical analysis was carried out by WHONET 5.6 software. Results among 366 strains of Enterococcus, 97 strains (26.50%) were Enterococcus faecalis, 137 strains (37.43%) were Enterococcus faecium, 26 strains (7.10%) were Enterococcus faecium, 106 strains (28.96%) were not identified. Enterococcus showed multidrug resistance to common antibiotics, sensitivity / resistance to vancomycin was 95.90 / 3.00, sensitivity / resistance to teicoplanin was 97.50 / 1.60, sensitivity / resistance to linazolamine was 99.70 / 0.30. Conclusion the drug resistance of Enterococcus bacteria is serious, and the drug resistance of different bacteria is different. The infection site is common in the urinary system. When treating Enterococcus infection, the clinicians should choose antibiotics reasonably according to the drug resistance characteristics and the results of drug sensitivity test. Strengthen the monitoring of bacterial resistance to prevent the spread of multi-drug-resistant bacteria.
【作者单位】：江汉大学附属笫三医院武汉市黄陂区人民医院药剂科;江汉大学医学院药学系;
【基金】：武汉市科技局科技计划基金资助项目(w2013027)
【分类号】：R446.5

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