基于双外周血压重建中心动脉压的方法及测量平台研究

发布时间：2018-07-25 19:18

【摘要】：中心动脉压在评价心血管疾病的发病机理方面比外周血压起着更直接的预测作用。临床上,获取中心动脉压的“金标准”是将专用空心针头经皮下股动脉穿入,通过导管将微型血压探头送到主动脉根部直接测量。然而,该方法具有一定的创伤性和临床风险性,且操作复杂,费用大,因此,临床上应用受到限制。由于外周血压与中心动脉压有直接的血流动力学关系,因此利用外周血压重建中心动脉压成为目前研究的主流方式。现有的方法在重建中心动脉压时存在的问题主要是:利用通用传递函数法不能满足个体化、自适应变化的需求;多通道盲辨识需在动脉的不同位置同时获取多个连续血压信号实际上不可能实现;利用血压血流准确重建中心动脉压所需的外周血流数据获取困难;单一依赖外周血压数据的重建方法由于信息缺失,其准确性受限。本课题通过研究、探索,建立了两级动脉血流动力学模型,并在此基础上,提出了利用双外周连续血压信号自适应重建中心动脉压的新原理和计算方法,弥补了血流信息的缺失,真正实现了个体化、自适应变化的需求。进行了数据仿真实验,通过与现有方法的对比,验证了原理的可行性。与广州医科大学附属第二医院联合开展了人体试验,对新方法的可行性作出了进一步的优化与改进。在目前比较成熟的单点无创连续血压测量方法的基础上,自行研究开发了一种双外周无创连续血压测量平台,完成了双外周连续血压的同步采集。
[Abstract]:Central arterial pressure plays a more direct role in predicting the pathogenesis of cardiovascular disease than peripheral blood pressure. Clinically, the "gold standard" for obtaining central arterial pressure is to penetrate the special hollow needle through the subcutaneous femoral artery and to measure the blood pressure microprobe directly through the aortic root through the catheter. However, the method has some traumatic and clinical risks, and its operation is complicated and costly, so its clinical application is limited. Since peripheral blood pressure has a direct hemodynamic relationship with central arterial pressure, reconstructing central arterial pressure with peripheral blood pressure has become the main research method. The main problems of the existing methods in the reconstruction of central arterial pressure are as follows: the general transfer function method can not meet the needs of individualization and adaptive change; In fact, it is impossible to obtain multiple continuous blood pressure signals simultaneously in different locations of arteries, and it is difficult to obtain the peripheral blood flow data needed for accurate reconstruction of central arterial pressure by using blood pressure flow. The accuracy of the reconstruction method which relies solely on peripheral blood pressure data is limited due to the lack of information. In this paper, a two-stage arterial hemodynamic model is established through research and exploration. On the basis of this model, a new principle and calculation method of adaptive reconstruction of central arterial pressure using continuous peripheral blood pressure signals are proposed. Make up for the lack of blood flow information, the real realization of individual, adaptive change of the demand. The feasibility of the principle is verified by comparing the data simulation results with the existing methods. The human body test was carried out jointly with the second affiliated Hospital of Guangzhou Medical University, and the feasibility of the new method was further optimized and improved. Based on the mature single point noninvasive continuous blood pressure measurement method, a double peripheral noninvasive continuous blood pressure measurement platform was developed, and the synchronous collection of double peripheral continuous blood pressure was completed.
【学位授予单位】：哈尔滨工业大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R443.5

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