膳食纤维对结肠癌患者术后免疫功能及炎性反应的影响

发布时间：2018-07-25 17:26

【摘要】：目的了解膳食纤维对术后结肠癌患者的临床治疗效果,探究其对结肠癌患者术后免疫功能及炎性反应的影响。方法采用前瞻性随机对照研究,选取病理诊断为结肠癌并且行结肠癌根治术的患者60例,其中膳食纤维生态肠内营养组(试验组)30例,生态肠内营养组(对照组)30例。分别于术前第1天、术后第2天、术后第7天清晨空腹抽取外周静脉血,检测血T淋巴细胞亚群(CD3+,CD4+,CD8+)和血清免疫球蛋白(IgA,IgG,IgM)等免疫指标,肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)等炎症反应指标。结果各时间点两组间的CD3+、CD8+、CD4+/CD8+、IgM水平差异无统计学意义(P0.05),而在术后第7天,试验组CD4+、IgA、IgG水平高于对照组,差异有统计学意义(P0.05);试验组TNF-α、IL-6水平低于对照组,差异有统计学意义(P0.05)。结论在结肠癌患者中,术后早期给予膳食纤维可提高患者机体免疫功能、减轻炎性反应。
[Abstract]:Objective to investigate the effect of dietary fiber on postoperative immune function and inflammatory response in patients with colon cancer. Methods A prospective randomized controlled study was conducted in 60 patients with colon cancer diagnosed by pathology and underwent radical resection of colon cancer, including 30 cases in the experimental group and 30 cases in the ecological enteral nutrition group and 30 cases in the control group. Peripheral venous blood was collected on the first day before operation, the second day after operation and the morning of 7 days after operation. The T lymphocyte subsets (CD3 T lymphocyte subsets) and serum immunoglobulin (IgA) immunoglobulin (IgG CD3) were detected in the first day of operation, the second day after operation and the morning of 7 days after operation. Tumor necrosis factor-伪 (TNF- 伪), interleukin-6 (IL-6), procalcitonin (PCT), and other inflammatory markers. Results there was no significant difference between the two groups at each time point (P0.05), but on the 7th day after operation, the level of CD4 IgA CD3 in the experimental group was higher than that in the control group (P0.05), and the level of TNF- 伪 IL-6 in the experimental group was lower than that in the control group (P0.05). Conclusion in colon cancer patients, early postoperative dietary fiber can improve the immune function of patients and alleviate inflammatory reaction.
【作者单位】：四川省肿瘤医院胃肠外科;四川大学华西医院胃肠外科中心;
【基金】：四川省科技厅科技支撑计划项目(No.2013FZ0091)资助
【分类号】：R735.35;R459.3

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