2012-2014年云南省结核分枝杆菌耐药分析

发布时间：2018-08-02 08:46

【摘要】：目的掌握云南省结核分枝杆菌耐药情况。方法对2012-2014年云南省结核分支杆菌省级参比实验室分离的结核分枝杆菌进行异烟肼(Isoniazide INH)、利福平(Rifampicin,RFP)、链霉素(Streptomycin,SM)、乙胺丁醇(Ethambutol,EMB)、氧氟沙星(Ofloxacin,OFX)、卡那霉素(Kanamycin,KM)药物敏感性检测。结果 2012-2014年,共计分离得到人型结核分枝菌628株;总耐药率为48.89%,耐多药率为27.07%,氧氟沙星耐药率为15.61%;耐药顺位为INHRFPSMOFXEMBKM;不同年龄组间总耐药率(χ~2=9.96,P=0.041)和耐多药率(χ~2=18.30,P=0.001)差异具有统计学意义,30~44岁年龄组为总耐药率和耐多药率最高人群;初治和复治患者间总耐药率(χ~2=29.48,P0.001,OR=3.63)、耐多药率(χ~2=44.17,P0.001,OR=4.26)和氧氟沙星耐药率(χ~2=26.33,P0.001,OR=3.45)差异均有统计学意义。结论云南省耐药结核病疫情严峻,初复治是耐药的危险因素。应加强随访管理力度,提升病人治愈率,同时规范氧氟沙星的使用,以达到有效控制耐药结核病疫情的目的。
[Abstract]:Objective to grasp the drug resistance of Mycobacterium tuberculosis in Yunnan province. Methods the Isoniazide INH, Li Fuping (Rifampicin, RFP), Streptomycin, SM, Ethambutol, EMB, and ofloxacin (Ofloxacin, OFX), and kanamycin were isolated from the provincial tuberculosis mycobacterium tuberculosis in Yunnan province for 2012-2014 years. Kanamycin (KM) drug sensitivity test. Results 2012-2014 years, a total of 628 strains of human Mycobacterium tuberculosis were isolated, the total resistance rate was 48.89%, the multidrug resistance rate was 27.07%, the rate of ofloxacin was 15.61%, the drug resistance was INHRFPSMOFXEMBKM, and the total drug resistance rate (x ~2=9.96, P=0.041) and the multidrug resistance rate (P=0.001) difference between different age groups were poor. The difference was statistically significant, the 30~44 age group was the highest drug resistance rate and the highest multidrug resistance rate; the total resistance rate (x ~2=29.48, P0.001, OR=3.63) between the primary and retreated patients, the multidrug resistance (x ~2=44.17, P0.001, OR=4.26) and ofloxacin resistance rates (x ~2=26.33, P0.001, OR=3.45) were statistically significant. Conclusion the drug-resistant tuberculosis in Yunnan Province The epidemic situation is severe and the initial retreatment is the risk factor of drug resistance. We should strengthen the follow-up management to improve the cure rate of the patients and standardize the use of ofloxacin so as to achieve the purpose of effective control of the epidemic situation of drug-resistant tuberculosis.
【作者单位】：云南省疾病预防控制中心结核病防治所;
【分类号】：R52;R446.5

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