空腹血浆内毒素水平与体质指数、胰岛素抵抗的相关性研究

发布时间：2018-07-31 16:04

【摘要】：目的研究不同BMI人群的空腹血浆内毒素(LPS)水平,分析LPS影响因素及其与BMI、IR的关系。方法纳入99例受试者,根据OGTT结果分为NGT与T2DM组,以BMI=28 kg/m2为切点,再分为肥胖(OB)与非肥胖(non-OB)亚组,检测血浆LPS、血清高敏C反应蛋白(hsC-RP)等。采用简单相关分析LPS与BMI、HOMA-IR等指标相关性、采用多元线性回归分析LPS及HOMA-IR的影响因素。结果无论是NGT还是T2DM,其肥胖亚组人群的空腹血浆LPS较非肥胖亚组高2~3倍,予以诊断为代谢性内毒素血症状态;LPS水平与BMI(r=0.307)、HbA1 c(r=0.454)、hsC-RP(r=0.254)、ALT(r=0.881)、AST(r=0.848)、HOMA-IR(r=0.509)、FPG(r=0.450)相关(P0.05);多元线性回归分析发现,BMI、HbA_1c是LPS的影响因素,BMI、LPS是HOMA-IR的影响因素。结论随着BMI的增加,血浆LPS水平逐渐升高,机体处于低度炎症、代谢性内毒素血症状态,可加重IR程度。
[Abstract]:Objective to study the fasting plasma endotoxin (LPS) levels in different BMI populations and to analyze the influencing factors of LPS and their relationship with BMI-IR. Methods 99 subjects were divided into NGT group and T2DM group according to the results of OGTT. Then they were divided into obese (OB) group and non-obese (non-OB) subgroup with BMI=28 kg/m2 as the cutting point. Plasma LPSand Gao Min C-reactive protein (hsC-RP) were detected. The correlation between LPS and BMIHOMA-IR was analyzed by simple correlation analysis, and the influencing factors of LPS and HOMA-IR were analyzed by multiple linear regression analysis. Results the fasting plasma LPS of obese subgroup was 3 times higher than that of non-obese subgroup, regardless of whether it was NGT or T2DM. The level of lipopolysaccharide in metabolic endotoxemia was correlated with BMI (rn0.307) HbA1c (rn0.454) hsC-RP (rn0.254) alt (rn0.881) AST (rn0.848) HOMA-IR (rr0.509) FPG (r0.450), and multivariate linear regression analysis showed that BMIMHBA 1c was the influencing factor of LPS. Conclusion with the increase of BMI, the level of plasma LPS increases gradually, the body is in low inflammation and metabolic endotoxemia, which can aggravate the degree of IR.
【作者单位】：南京医科大学第一附属医院内分泌科;苏州科技城医院内分泌科;
【基金】：国家自然科学基金(81170747) 江苏省自然科学基金(SBK2016022587)
【分类号】：R446.1

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