非污染区普通人群尿中多环芳烃羟基代谢产物初步调查

发布时间：2018-08-12 19:01

【摘要】：为了解非污染区普通人群尿液中多环芳烃羟基代谢产物的水平,探讨其在非污染区人群中的内暴露情况,为污染区人群中多环芳烃的负荷研究提供基础资料。于2014年9月在农村非污染区随机选取63名村民为研究对象,收集其晨尿中段,采用高效液相色谱法检测尿液中多种单羟基多环芳烃的浓度。结果显示成人尿样中1-羟基芘、3-羟基苯并[a]芘、1-羟基菲+9-羟基菲、2-羟基菲+3-羟基菲、1-羟基萘、2-羟基萘、2-羟基芴、9-羟基芴的检出率分别16.28%,4.65%,23.26%,27.91%,55.81%,65.12%,97.67%,44.19%;平均浓度分别为2.6205,3.9894,0.5424,0.5644,150.339 4、7.508 3、2.232 4、35.728 3μg/g cr。儿童尿样中1-羟基芘和3-羟基苯并[a]芘未检出;1-羟基菲+9-羟基菲、2-羟基菲+3-羟基菲、1-羟基萘、2-羟基萘、2-羟基芴、9-羟基芴的检出率分别为15%,25%,60%,35%,100%,45%,平均浓度分别为0.350 6、0.119 4、159.279 8、1.571 4、1.789 2、28.082 8μg/g cr。其中,成人尿样2-羟基萘的检出率和检出水平高于儿童(P0.05)。提示非污染区普通人群尿样OH-PAHs均有一定的检出率;成人和儿童OH-PAHs水平存在差异,为进一步开展PAHs代谢产物在污染区人群的暴露提供了基础数据。
[Abstract]:In order to understand the level of polycyclic aromatic hydrocarbons (PAHs) hydroxyl metabolites in urine of the general population in non-polluted areas, and to explore the internal exposure of PAHs in the non-polluted population, the basic data were provided for the load study of PAHs in the polluted population. Sixty-three villagers were randomly selected from rural non-polluted areas in September 2014 to collect the middle part of their morning urine. The concentrations of various monohydroxy polycyclic aromatic hydrocarbons (PAHs) in urine were determined by HPLC. The results showed that the detection rate of 1-hydroxy pyrene 3-hydroxybenzo [a] pyrene was 2.62053.98940.540.5644150.339 47.728 渭 g / g, respectively. The detection rate of 1-hydroxy-phenanthroline 2-hydroxy-phenanthroline 3-hydroxy-phenanthroline was 16.2884.65 ~ 23.26.The average concentration was 2.62053.98940.240.5644150.339 47.3502.232,232.232,435.728 3 渭 g / g crr. The detectable rates of 1-hydroxypyrene and 3-hydroxybenzo [a] pyrene in urine samples of children were 15250.60%, respectively. The average concentrations of 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 2-hydroxyphenanthroline, 2-hydroxylnaphthalene, 2-hydroxyfluorene and 9-hydroxyfluorene were 0.350 6, 0.119, 4159.279 4159.279, 1.571, 1.789, 228.082 8 渭 g / g cr. respectively. The detection rate and detection level of 2-hydroxynaphthalene in adult urine samples were higher than those in children (P0.05). The results suggested that there was a positive rate of OH-PAHs in urine samples of non-polluted population, and there were differences in OH-PAHs levels between adults and children, which provided basic data for further exposure of PAHs metabolites in polluted population.
【作者单位】：中国辐射防护研究院国家环境保护环境与健康重点实验室;
【分类号】：R114;R446.12

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