磁共振扩散加权成像与直肠癌病理预后因素的相关性研究

发布时间：2018-08-13 09:30

【摘要】：目的探讨磁共振扩散加权成像ADC值与直肠癌病理预后因素的相关性。方法回顾性搜集45例经病理证实且未行辅助治疗而直接手术治疗的直肠癌患者的病理资料,并根据病理分化程度、T分期、N分期以及脉管、周围神经及直肠系膜筋膜受侵犯状态和免疫组织化学EGFR及P53表达情况进行分组。测量直肠癌的肿瘤组织b=800 s/mm2时的ADC值,分析各组之间肿瘤ADC值的相关关系。结果高、中、低分化组的ADC值依次降低,且差异具有统计学意义(P=0.016)。直肠癌N+组的ADC值低于N0组,差异具有统计学意义(P=0.037)。而不同病理T分期、脉管及周围神经受侵、直肠系膜筋膜受侵及癌结节不同分组间肿瘤平均ADC值的差异无统计学意义。EGFR、P3表达阳性组的平均ADC值均低于表达阴性组,但差异均无统计学意义(P0.05)。结论直肠癌的ADC值与肿瘤的分化程度及淋巴结转移具有相关性,可有望通过ADC值的定量描述来评估肿瘤的生物学行为。
[Abstract]:Objective to investigate the correlation between ADC value of diffusion-weighted Mr imaging and pathological prognostic factors of rectal cancer. Methods the pathological data of 45 patients with rectal cancer confirmed by pathology and without adjuvant therapy were retrospectively collected. Peripheral nerve and mesenteric fascia were invaded and immunohistochemical expression of EGFR and p53 were divided into groups. The ADC value of tumor tissue of rectal cancer at 800 s/mm2 was measured and the correlation of tumor ADC value between each group was analyzed. Results the ADC values of high, middle and low differentiation groups decreased in turn, and the difference was statistically significant (P0. 016). The ADC of group N was significantly lower than that of group N (P 0.037). However, there was no significant difference in the mean ADC value of tumor between different groups of T stage, vascular and peripheral nerve invasion, mesenteric fascia invasion and cancer nodule. The average ADC value of positive EGFR P3 group was lower than that of negative expression group. But the difference was not statistically significant (P0.05). Conclusion the ADC value of rectal cancer is correlated with the degree of tumor differentiation and lymph node metastasis. The quantitative description of ADC value can be used to evaluate the biological behavior of the tumor.
【作者单位】：同济大学附属杨浦医院放射科;同济大学附属杨浦医院病理科;同济大学附属同济医院放射科;
【基金】：2015年上海市杨浦区科委、卫计委青年课题基金项目(编号:7)
【分类号】：R445.2;R735.37

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