循证药学在连续性肾脏替代治疗期间抗凝治疗决策中的应用
发布时间：2018-08-27 06:35
【摘要】：目的:探讨循证药学在连续性肾脏替代治疗(CRRT)期间抗凝药物治疗中协助实施最佳治疗方案的作用。方法:以1例患者行CRRT期间出现血小板减少时抗凝药物治疗决策为例,介绍临床药师介入临床,通过循证药学方法结合临床数据,分析高出血风险及血小板减少患者行CRRT期间选用阿加曲班抗凝治疗的证据,并跟踪其疗效和安全性,对药物治疗过程进行综合评估的相关情况。结果:分析检索到高出血风险及血小板减少患者行CRRT期间选用阿加曲班抗凝治疗的文献共5篇,其中有1篇系统评价、1篇随机对照研究、3篇列队研究。将其最佳证据应用到该例患者的临床实践中并取得了较好效果,患者血小板和凝血指标改善,无出血和栓塞并发症发生。结论:循证药学在CRRT期间抗凝治疗决策中可发挥重要作用。
[Abstract]:Objective: to investigate the role of evidence-based pharmacology in the implementation of the best therapeutic regimen in the treatment of continuous renal replacement therapy (CRRT) during anticoagulant therapy. Methods: taking one patient with thrombocytopenia during CRRT as an example, the intervention of clinical pharmacists and clinical data were introduced. To analyze the evidence of Agatripine anticoagulant therapy in patients with high risk of hemorrhage and thrombocytopenia during CRRT, and to follow up its efficacy and safety, and to evaluate the process of drug therapy. Results: a total of 5 papers were collected from the patients with high risk of hemorrhage and thrombocytopenia who were treated with Agatripine anticoagulant therapy during CRRT, including 1 systematic evaluation and 1 randomized controlled study and 3 separate studies. The best evidence was applied to the clinical practice of the patient and good results were obtained. The platelet and coagulation indexes were improved without bleeding and embolization complications. Conclusion: Evidence-based pharmacology may play an important role in anticoagulant therapy decision making during CRRT.
【作者单位】： 南京医科大学附属苏州医院药学部;上海交通大学医学院附属新华医院药学部;
【分类号】：R459.5
本文编号：2206425
[Abstract]:Objective: to investigate the role of evidence-based pharmacology in the implementation of the best therapeutic regimen in the treatment of continuous renal replacement therapy (CRRT) during anticoagulant therapy. Methods: taking one patient with thrombocytopenia during CRRT as an example, the intervention of clinical pharmacists and clinical data were introduced. To analyze the evidence of Agatripine anticoagulant therapy in patients with high risk of hemorrhage and thrombocytopenia during CRRT, and to follow up its efficacy and safety, and to evaluate the process of drug therapy. Results: a total of 5 papers were collected from the patients with high risk of hemorrhage and thrombocytopenia who were treated with Agatripine anticoagulant therapy during CRRT, including 1 systematic evaluation and 1 randomized controlled study and 3 separate studies. The best evidence was applied to the clinical practice of the patient and good results were obtained. The platelet and coagulation indexes were improved without bleeding and embolization complications. Conclusion: Evidence-based pharmacology may play an important role in anticoagulant therapy decision making during CRRT.
【作者单位】： 南京医科大学附属苏州医院药学部;上海交通大学医学院附属新华医院药学部;
【分类号】：R459.5
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