新疆北疆地区哈萨克族人群Rh阴性血清学表型分布调查
发布时间：2018-10-17 20:26
【摘要】：目的了解新疆北疆地区哈萨克族人群Rh阴性血型表型血清学的多态性,为临床科学、安全输血提供参考依据。对新生儿溶血病也具有重要的临床意义。方法随机整群抽取新疆北疆地区不同部落哈萨克族人群的无关个体22 660人,采用试管法检测Rh D抗原。Rh D阴性样本,用间接抗球蛋白试验确认,用抗-C、抗-c、抗-E、抗-e单克隆抗血清检测表型。结果检出Rh(D)阴性个体673例,弱D21例,新疆北疆地区哈萨克族Rh(D)阴性率为2.97%,Rh阴性表型在ABO血型中的分布为OBAAB,血清学表型频率dccee(85.74%)d Ccee(10.55%)dcc Ee(2.52%)dc CEe(0.89%)d CCee(0.30%)。单倍型基因频率dce(0.924 171)d Ce(0.058 558)dc E(0.013 614)d CE(0.003 657)。结论新疆北疆地区哈萨克族人群Rh阴性血型表型分布,具有本民族特征。哈萨克族具有白种人和东方人渗透、融合的特征。
[Abstract]:Objective to investigate the phenotypic polymorphism of Rh negative blood group in Kazakh population in northern Xinjiang, and to provide reference for clinical science and safe blood transfusion. It also has important clinical significance for neonatal hemolytic disease. Methods A total of 22 660 unrelated individuals from Kazak ethnic groups from different tribes in northern Xinjiang were randomly selected. Rh D antigen. Rh D negative samples were detected by tube method and confirmed by indirect antiglobulin test. The phenotypes were detected by anti-C, anti-c, anti-E, anti-e monoclonal antisera. Results there were 673 Rh (D) negative individuals, 21 weak D cases and 2.97 Rh negative phenotype in ABO blood group of Kazak nationality in northern Xinjiang. The frequency of OBAAB, serological phenotype was dccee (85.74%) d Ccee (10.55%) dcc Ee (2.52%) dc CEe (0.89%) d CCee (0.30%). Haplotype gene frequency dce (0.924 171) d Ce (0.058 558) dc E (0.013 614) d CE (0.003 657). Conclusion the phenotypic distribution of Rh negative blood group in Kazak population in northern Xinjiang is of its own ethnic characteristics. Kazakh people have the characteristics of infiltration and integration between Caucasians and oriental people.
【作者单位】： 新疆伊犁哈萨克自治州奎屯医院输血科;新疆伊犁哈萨克自治州友谊医院输血科;新疆维吾尔自治区人民医院输血科;
【分类号】：R457.11
，
本文编号：2277859
[Abstract]:Objective to investigate the phenotypic polymorphism of Rh negative blood group in Kazakh population in northern Xinjiang, and to provide reference for clinical science and safe blood transfusion. It also has important clinical significance for neonatal hemolytic disease. Methods A total of 22 660 unrelated individuals from Kazak ethnic groups from different tribes in northern Xinjiang were randomly selected. Rh D antigen. Rh D negative samples were detected by tube method and confirmed by indirect antiglobulin test. The phenotypes were detected by anti-C, anti-c, anti-E, anti-e monoclonal antisera. Results there were 673 Rh (D) negative individuals, 21 weak D cases and 2.97 Rh negative phenotype in ABO blood group of Kazak nationality in northern Xinjiang. The frequency of OBAAB, serological phenotype was dccee (85.74%) d Ccee (10.55%) dcc Ee (2.52%) dc CEe (0.89%) d CCee (0.30%). Haplotype gene frequency dce (0.924 171) d Ce (0.058 558) dc E (0.013 614) d CE (0.003 657). Conclusion the phenotypic distribution of Rh negative blood group in Kazak population in northern Xinjiang is of its own ethnic characteristics. Kazakh people have the characteristics of infiltration and integration between Caucasians and oriental people.
【作者单位】： 新疆伊犁哈萨克自治州奎屯医院输血科;新疆伊犁哈萨克自治州友谊医院输血科;新疆维吾尔自治区人民医院输血科;
【分类号】：R457.11
，
本文编号：2277859
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