2015年医院临床常见细菌耐药性监测分析

发布时间：2018-10-18 07:19

【摘要】：目的了解广州市番禺区中心医院2015年临床分离菌的分布及耐药情况,为指导临床工作提供依据。方法对2015年1月-12月临床送检的分离株进行药敏试验采用纸片扩散法(KB法),2014年CLSI标准判断药敏结果,用WHONET5.6软件进行数据分析。结果 2015年共分离细菌4 212株,其中革兰阴性菌3 132株,占74.4%,革兰阳性菌1 080株,占25.6%,检出前3位的细菌分别是大肠埃希菌956株占22.7%,肺炎克雷伯菌588株占14.0%,铜绿假单胞菌584株占13.9%,耐甲氧西林金黄色葡萄球菌和耐甲氧西林凝固酶阴性葡萄球菌检出率分别是26.6%和78.6%,未发现耐万古霉素肠球菌,产ESBLs大肠埃希菌和肺炎克雷伯菌的检出率分别是43.5%和19.0%,检出3株耐碳青霉烯类大肠埃希菌。结论番禺区总体耐药形式相对缓和,耐药菌以耐甲氧西林葡萄球菌和产ESBL肠杆菌比率高,检出3株耐烯青霉稀类大肠埃希菌应引起重视,应加强细菌耐药性监测和多药耐药菌管理,预防多药耐药菌院内传播及合理使用抗菌药物。
[Abstract]:Objective to investigate the distribution and drug resistance of clinical isolates in Panyu District Central Hospital of Guangzhou in 2015. Methods Drug sensitivity test was carried out in clinical isolates from January to December 2015 by KB method. The results of drug sensitivity were judged by CLSI standard in 2014. The data were analyzed by WHONET5.6 software. Results A total of 4 212 strains of bacteria were isolated in 2015, of which 3 132 were Gram-negative bacteria (74.4%), 1 080 were Gram-positive bacteria. The top three bacteria were Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase negative Staphylococcus, respectively. The rates of vancomycin-resistant Enterococcus were 26.6% and 78.6%, respectively, and no vancomycin resistant Enterococcus was found. The positive rates of ESBLs producing Escherichia coli and Klebsiella pneumoniae were 43.5% and 19.0%, respectively. Three strains of carbapene-resistant Escherichia coli were detected. Conclusion the overall drug resistance of Panyu district is relatively mild. The ratio of methicillin-resistant Staphylococcus to Enterobacter ESBL is high. The detection of three strains of Escherichia coli resistant to penicillium should be paid more attention to. The surveillance of bacterial resistance and the management of multidrug resistant bacteria should be strengthened to prevent the spread of multidrug resistant bacteria in hospital and the rational use of antimicrobial agents.
【作者单位】：广州市番禺区中心医院呼吸科;广州市番禺区中心医院感染控制科;广州市番禺区中心医院检验科;广州市番禺区中心医院重症医学科;
【分类号】：R378.2+1

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