集束化治疗对ICU患者中心静脉导管相关性血流感染的影响

发布时间：2018-10-22 16:07

【摘要】：目的对集束化治疗实施前后医院ICU患者发生中心静脉导管相关性血流感染(CLABSI)进行监测,观察其CLABSI发生率的变化及病原菌的流行病学趋势。方法选择医院2010年1月1日-2014年12月31日入住ICU并留置中心静脉导管的患者进行研究,2010年1月1日-2011年12月31日为集束化应用前(第一阶段),2012年1月1日至2014年12月31日为静脉集束化治疗后(第二阶段)。比较两个阶段CLABSI的发生率以及病原菌分布的变化。结果纳入患者4 801例,共243例发生CLABSI,总发生率5.06%,其中第一阶段120例患者发生CLABSI,发生率7.21%,第二阶段123例患者发生CLABSI,发生率4.39%,不同阶段比较,差异有统计学意义(P0.05)。结论实施集束化治疗可以降低CLABSI的发生率,在5年观察期间导致CLABSI的不同致病菌的构成比发生了变化。
[Abstract]:Objective to monitor the incidence of central venous catheter related blood stream infection (CLABSI) in ICU patients before and after cluster therapy, and to observe the incidence of CLABSI and the epidemiological trend of pathogenic bacteria. Methods the patients who were admitted to ICU from January 1, 2010 to December 31, 2014 and placed in central venous catheter were studied. January 1, 2010-December 31, 2011 were used before cluster application (phase I), January 1, 2012 to 2014, from 1 January, 2012 to 2014, from January 1, 2010 to December 31, 2011, from January 1 to December 31, 2011. December 31, after intravenous cluster therapy (stage 2). The incidence of CLABSI and the distribution of pathogenic bacteria were compared between the two stages. Results the total incidence of CLABSI, was 5.06% in 243 patients, including 7.21 in the first stage and 4.39 in the 123 patients in the second stage. The difference was statistically significant (P0.05). Conclusion the incidence of CLABSI can be reduced by cluster therapy, and the composition ratio of different pathogens causing CLABSI has changed during the observation period of 5 years.
【作者单位】：天津市第一中心医院重症医学科;
【基金】：天津市卫生和计划委员会科技基金资助项目(2015KZ019) 卫生部国家临床重点专科建设项目(2011[873])
【分类号】：R459.7

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