老年冠心病患者血清骨保护素、胱抑素C、YKL-40水平变化的临床意义

发布时间：2018-11-03 14:42

【摘要】：目的探讨老年冠心病(CHD)患者血清骨保护素(OPG)、胱抑素C、几丁质酶-3(YKL-40)水平变化的临床意义。方法疑似冠心病的老年患者67例,均行冠状动脉造影(CAG)。其中确诊为冠心病的患者44例(CHD组),根据患者的临床表现分为劳力型心绞痛20例(SAP组)和急性冠状综合征24例(ACS组);根据冠脉病变支数分为单支病变组(18例)和多支病变组(26例);23例CAG正常者作为对照组。对比分析不同临床分型和不同冠脉病变支数CHD患者与对照组胱抑素C、OPG和YKL-40水平的变化。结果胱抑素C水平:ACS组最低,SAP组次之,对照组最高(F=19.9608,P0.05);对照组最高,单支病变组次之,多支病变组最低(F=19.2670,P0.05)。OPG水平:ACS组最高,SAP组次之,对照组最低(F=14.1696,P0.05);多支病变组最高,单支病变组次之,对照组最低(F=15.7612,P0.05)。YKL-40水平:ACS组最高,SAP组次之,对照组最低(F=13.5517,P0.05);多支病变组最高,单支病变组次之,对照组最低(F=13.2829,P0.05)。结论胱抑素C、OPG和YKL-40水平在一定的程度上可作为诊断CHD特别是ACS的参考指标,为冠心病患者临床分型提供依据,亦可间接反映患者冠脉病变的严重程度。
[Abstract]:Objective to investigate the clinical significance of serum osteoprotegerin (OPG), cystatin C and chitinase 3 (YKL-40) levels in elderly patients with coronary heart disease (CHD). Methods Sixty-seven elderly patients with suspected coronary heart disease underwent coronary angiography (CAG). 44 patients with coronary heart disease (CHD group) were divided into exertional angina pectoris group (SAP group) and acute coronary syndrome group (ACS group). According to the number of coronary artery lesion branches, the patients were divided into single vessel lesion group (18 cases) and multivessel lesion group (26 cases), and 23 cases of normal CAG as control group. The levels of cystatin (CHD) and cystatin (YKL-40) in CHD patients with different clinical types and different coronary branches were compared with those in the control group. Results the level of cystatin C was the lowest in ACS group, followed by SAP group, and the highest in control group (P 0.05). The control group was the highest, the single vessel lesion group was the second, and the multivessel lesion group was the lowest (F _ (19.2670) P _ (0.05). OPG level: the ACS group was the highest, the SAP group was the second, and the control group was the lowest (F _ (14.1696) P 0.05). The level of YKL-40 was the highest in ACS group, followed by SAP group, and the lowest in control group (FN 13.5517 P 0.05). The multivessel lesion group was the highest, the single vessel lesion group was the second, and the control group was the lowest (F _ (13.2829) P 0.05). Conclusion the levels of cystatin C OPG and YKL-40 can be used as a reference index for the diagnosis of CHD, especially for ACS, which can provide evidence for clinical classification of patients with coronary heart disease and indirectly reflect the severity of coronary artery disease.
【作者单位】：河北医科大学第三医院检验科;河北医科大学第三医院心内2科;
【基金】：河北省医学科学研究重点课题(20110420)
【分类号】：R541.4;R446.11

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