脓毒血症伴发心力衰竭患者血清胱抑素C水平与临床症状的相关性研究

发布时间：2018-11-05 12:57

【摘要】：目的探讨血清胱抑素C对脓毒血症患者心力衰竭发生的影响及相关因素,为临床诊治提供参考。方法选择2014年2月-2016年2月脓毒血症患者136例,其中47例伴发急性心力衰竭,比较不同患者血清胱抑素C水平的差异,并将左室射血分数(LVEF)、左心室舒张末内径(LVDd)、E/e'等指标与胱抑素C水平进行相关分析。结果与单纯脓毒血症患者相比,伴发急性心力衰竭的患者血清胱抑素C的浓度更高(1.84±0.45mg/L vs1.15±0.27mg/L),差异有统计学意义(P0.05);胱抑素C的水平与年龄、LVEF、LVDd、E/e'等之间存在显著的相关性(P均0.05);血清胱抑素C浓度≥1.58mg/L者发生急性心力衰竭的风险是浓度1.58 mg/L者的1.68倍,而且发生LVEF≤40%、LVDd≥60mm、E/e'≥17发生的风险也增高。结论伴发心力衰竭的脓毒血症患者血清胱抑素C水平明显增高,且升高的比例与发生急性心力衰竭的风险、异常心脏功能指标呈正相关,提示胱抑素C可作为临床早期识别脓毒血症患者发生急性心力衰竭的生物学指标。
[Abstract]:Objective to investigate the effect of serum cystatin C on the occurrence of heart failure in patients with sepsis and to provide reference for clinical diagnosis and treatment. Methods 136 patients with sepsis from February 2014 to February 2016 were selected, 47 of whom were associated with acute heart failure. The serum cystatin C levels in different patients were compared. Left ventricular ejection fraction (LVEF),) and left ventricular end-diastolic diameter (LVDd),) were compared. The correlation between E / E 'and cystatin C levels was analyzed. Results the concentration of cystatin C in patients with acute heart failure was significantly higher than that in patients with simple sepsis (1.84 卤0.45mg/L vs1.15 卤0.27mg/L) (P0.05). There was a significant correlation between the level of cystatin C and age, LVEF,LVDd,E/e', etc. The risk of acute heart failure in patients with serum cystatin C 鈮，

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