金黄色葡萄球菌血流感染的临床分布与耐药性分析

发布时间：2018-11-11 15:25

【摘要】：目的了解金黄色葡萄球菌血流感染的临床分布及细菌耐药情况,为临床合理用药提供参考。方法采集医院2009年1月-2015年5月由金黄色葡萄球菌致血流感染76例住院患者的相关临床资料,就其临床分布及细菌耐药情况进行回顾性分析。结果金黄色葡萄球菌血流感染多见于老年患者及新生儿;主要分布于肾脏病科(35.5%)、新生儿科(13.2%)及ICU(13.2%)。金黄色葡萄球菌对青霉素耐药率最高为94.7%,对替考拉宁、万古霉素、利奈唑胺敏感率均为100.0%,对夫西地酸的敏感率为96.1%。耐甲氧西林金黄色葡萄球菌(MRSA)检出率达40.8%,其对庆大霉素、克林霉素、左氧氟沙星、磺胺甲恶唑/甲氧苄啶的敏感率明显低于甲氧西林敏感金黄色葡萄球菌(MSSA)(P0.05)。社区与医院获得性感染的MRSA或MSSA分别对常用抗菌药物敏感率进行比较均无显著差异性。结论金黄色葡萄球菌血流感染患者临床分布相对集中,MRSA检出率较高,细菌耐药性严重,临床应及早进行抗感染治疗,合理选择抗菌药物避免细菌耐药性的产生。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of Staphylococcus aureus infection and to provide reference for rational drug use. Methods from January 2009 to May 2015, 76 inpatients with blood flow infection caused by Staphylococcus aureus were collected and their clinical distribution and bacterial resistance were analyzed retrospectively. Results Staphylococcus aureus blood flow infection was mainly found in the elderly patients and newborns, mainly in the Department of Kidney Science (35.5%), the Neonatal Department (13.2%) and the ICU (13.2%). Staphylococcus aureus had the highest drug resistance rate to penicillin 94.7, to teicoplanin, vancomycin and linazolamine, the sensitivity rate was 100.0and the sensitivity rate to fusidic acid was 96.1g. The detection rate of (MRSA) in methicillin-resistant Staphylococcus aureus was 40.8. The positive rates of gentamicin, clindamycin and levofloxacin were determined. The sensitivity of sulfamethoxazole / trimethoprim was significantly lower than that of methicillin-sensitive Staphylococcus aureus (P0.05). There was no significant difference between MRSA and MSSA in community and nosocomial infection. Conclusion the clinical distribution of Staphylococcus aureus blood stream infection patients is relatively concentrated, the detection rate of MRSA is relatively high, and the bacterial resistance is serious.
【作者单位】：南京医科大学第二附属医院呼吸内科;南京医科大学第二附属医院微生物室;
【分类号】：R378.1+1

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